Clinical features of monkeypox in adults
DOI:
https://doi.org/10.56294/saludcyt2022184Keywords:
Monkeypox, ; Monkeypox VirusAbstract
Introduction: monkeypox (MPV) is a rare, self-limiting disease that has occurred in various regions of the world. It is endemic to western and central Africa. At the beginning the symptoms are non-specific such as headache, asthenia, lethargy, myalgia and fever that begins before the appearance of skin eruptions which go through stages of evolution (ranging from macules to scabs).
Objective: to describe the clinical characteristics of monkeypox in adults.
Methods: a bibliographic review was carried out, through an electronic search in the main databases (PubMed, Taylor & Francis, Scopus and ScienceDirect). It was included articles published between January 01 st, 2018 and October 25th, 2022.
Results: characteristics of monkeypox at different stages of the disease were identified. Among the most prevalent lesions are vesiculopustular skin lesions, followed by fever, headache and pruritus; and among the least frequent were arthralgia, myalgia, odynophagia, and lesions in the oral and perioral region.
Conclusions: it is concluded that there are different clinical characteristics in each stage of monkeypox
References
1. Beer EM, Rao VB. A systematic review of the epidemiology of human monkeypox outbreaks and implications for outbreak strategy. PLoS Negl Trop Dis. 2019;13(10):e0007791. https://doi.org/10.1371/journal.pntd.0007791.
2. Rizk JG, Lippi G, Henry BM, Forthal DN, Rizk Y. Prevention and Treatment of Monkeypox. Drugs. 2022;82(9):957-63. https://doi.org/10.1007/s40265-022-01742-y.
3. Petersen E, Kantele A, Koopmans M, Asogun D, Yinka-Ogunleye A, Ihekweazu C, et al. Human Monkeypox: Epidemiologic and Clinical Characteristics, Diagnosis, and Prevention. Infect Dis Clin North Am. 2019;33(4):1027-43. https://doi.org/10.1016/j.idc.2019.03.001.
4. Heymann DL, Simpson K. The Evolving Epidemiology of Human Monkeypox: Questions Still to Be Answered. J Infect Dis. 2021;223(11):1839-41. https://doi.org/10.1093/infdis/jiab135.
5. Bothra A, Maheswari A, Singh M, Pawar M, Jodhani K. Cutaneous manifestations of viral outbreaks. Australas J Dermatol. 2021;62(1):27-36. https://doi.org/10.1111/ajd.13421.
6. Liu D, Chi Y, Song P, Zeng X, Du L, Chen Y, et al. Risk factors, clinical manifestation, precaution, and management of monkeypox. J Evid-Based Med. 2022;15(3):183-6. https://doi.org/10.1111/jebm.12490.
7. Adnan N, Haq Z ul, Malik A, Mehmood A, Ishaq U, Faraz M, et al. Human monkeypox virus: An updated review. Medicine (Baltimore). 2022;101(35):e30406. https://doi.org/10.1097/MD.0000000000030406.
8. Kumar N, Acharya A, Gendelman HE, Byrareddy SN. The 2022 outbreak and the pathobiology of the monkeypox virus. J Autoimmun. 2022;131:102855. https://doi.org/10.1016/j.jaut.2022.102855.
9. Kaler J, Hussain A, Flores G, Kheiri S, Desrosiers D. Monkeypox: A Comprehensive Review of Transmission, Pathogenesis, and Manifestation. Cureus. 2022;14(7). https://doi.org/10.7759/cureus.26531.
10. Moore MJ, Rathish B, Zahra F. Mpox (Monkeypox). Treasure Island (FL): StatPearls; 2022.
11. Benites-Zapata VA, Ulloque-Badaracco JR, Alarcon-Braga EA, Hernandez-Bustamante EA, Mosquera-Rojas MD, Bonilla-Aldana DK, et al. Clinical features, hospitalisation and deaths associated with monkeypox: a systematic review and meta-analysis. Ann Clin Microbiol Antimicrob. 2022;21(1):36. https://doi.org/10.1186/s12941-022-00527-1.
12. Patel A, Bilinska J, Tam JCH, Fontoura DDS, Mason CY, Daunt A, et al. Clinical features and novel presentations of human monkeypox in a central London centre during the 2022 outbreak: descriptive case series. BMJ. 2022;378:e072410. https://doi.org/10.1136/bmj-2022-072410.
13. Jang YR, Lee M, Shin H, Kim JW, Choi M min, Kim YM, et al. The First Case of Monkeypox in the Republic of Korea. J Korean Med Sci. 2022;37(27). https://doi.org/10.3346/jkms.2022.37.e224.
14. Fischer F, Mehrl A, Kandulski M, Schlosser S, Müller M, Schmid S. Monkeypox in a Patient with Controlled HIV Infection Initially Presenting with Fever, Painful Pharyngitis, and Tonsillitis. Medicina (Mex). 2022;58(10):1409. https://doi.org/10.3390/medicina58101409.
15. Tarín-Vicente EJ, Alemany A, Agud-Dios M, Ubals M, Suñer C, Antón A, et al. Clinical presentation and virological assessment of confirmed human monkeypox virus cases in Spain: a prospective observational cohort study. The Lancet. 2022;400(10353):661-9. https://doi.org/10.1016/S0140-6736(22)01436-2.
16. Ajmera KM, Goyal L, Pandit T, Pandit R. Monkeypox – An emerging pandemic. IDCases. 2022;29:e01587. https://doi.org/10.1016/j.idcr.2022.e01587.
17. Adler H, Gould S, Hine P, Snell LB, Wong W, Houlihan CF, et al. Clinical features and management of human monkeypox: a retrospective observational study in the UK. Lancet Infect Dis. 2022;22(8):1153-62. https://doi.org/10.1016/S1473-3099(22)00228-6.
18. Yinka-Ogunleye A, Aruna O, Dalhat M, Ogoina D, McCollum A, Disu Y, et al. Outbreak of human monkeypox in Nigeria in 2017–18: a clinical and epidemiological report. Lancet Infect Dis. 2019;19(8):872-9. https://doi.org/10.1016/S1473-3099(19)30294-4.
19. Hatmal MM, Al-Hatamleh MAI, Olaimat AN, Ahmad S, Hasan H, Ahmad Suhaimi NA, et al. Comprehensive literature review of monkeypox. Emerg Microbes Infect. 2022;11(1):2600-31. https://doi.org/10.1080/22221751.2022.2132882.
20. Tusabe F, Tahir IM, Akpa CI, Mtaki V, Baryamujura J, Kamau B, et al. Lessons Learned from the Ebola Virus Disease and COVID-19 Preparedness to Respond to the Human Monkeypox Virus Outbreak in Low- and Middle-Income Countries. Infect Drug Resist. 2022;15:6279-86. https://doi.org/10.2147/IDR.S384348.
21. Johri N, Kumar D, Nagar P, Maurya A, Vengat M, Jain P. Clinical manifestations of human monkeypox infection and implications for outbreak strategy. Health Sci Rev. 2022;5:100055. https://doi.org/10.1016/j.hsr.2022.100055.
22. Okonji OC, Okonji EF. Monkeypox during COVID-19 era in Africa: Current challenges and recommendations. Ann Med Surg. 2022;81:104381. https://doi.org/10.1016/j.amsu.2022.104381.
23. Hraib M, Jouni S, Albitar MM, Alaidi S, Alshehabi Z. The outbreak of monkeypox 2022: An overview. Ann Med Surg. 2022;79:104069. https://doi.org/10.1016/j.amsu.2022.104069.
24. Gong Q, Wang C, Chuai X, Chiu S. Monkeypox virus: a re-emergent threat to humans. Virol Sin. 2022;37(4):477-82. https://doi.org/10.1016/j.virs.2022.07.006.
25. Dou YM, Yuan H, Tian HW. Monkeypox virus: past and present. World J Pediatr. 2022:1-7. https://doi.org/10.1007/s12519-022-00618-1.
26. Shafaati M, Zandi M. State-of-the-art on monkeypox virus: an emerging zoonotic disease. Infection. 2022;50:1425–1430. https://doi.org/10.1007/s15010-022-01935-3.
27. Zhu M, Ji J, Shi D, Lu X, Wang B, Wu N, et al. Unusual global outbreak of monkeypox: what should we do? Front Med 2022;16(4):507-17. https://doi.org/10.1007/s11684-022-0952-z.
28. Aljabali AAA, Obeid MA, Nusair MB, Hmedat A, Tambuwala MM. Monkeypox virus: An emerging epidemic. Microb Pathog. 2022;173:105794. https://doi.org/10.1016/j.micpath.2022.105794.
29. Lahariya C, Thakur A, Dudeja N. Monkeypox Disease Outbreak (2022): Epidemiology, Challenges, and the Way Forward. Indian Pediatr. 2022;59(8):636-42. https://doi.org/10.1007/s13312-022-2578-2.
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Copyright (c) 2022 Germania Elizabeth Ortiz Freire , Claudia Gabriela Clavijo Rosales, Andrea Melissa Márquez Torres , Paola Yessenia Quito Ochoa (Author)
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