Evaluate the Frequency of EosinophilicEsophagitisin Individuals with Refractory GERD
DOI:
https://doi.org/10.56294/saludcyt2024.920Keywords:
EoE, refractory GERD, frequent endoscopic, elder patientsAbstract
Background: Theeosinophilic infiltrate of the esophagus mucosal distinguishes the esophageal ailment known as Eosinophilicesophagitis (EoE). This study aims to determine the frequency of EoE in patients with gastroesophageal reflux disease (GERD), a gastro esophageal reflux condition that is persistent.
Methods: The 248 children in total hadelectiveupper gastrointestinal endoscopy (UGIE) during the study period were separated in tosix groups: individuals without a history of steroid usage and those with outanesophageal biopsyforthrombocytopenia. As a result, 200 people participated in the study total.
Results: After an evaluation of 200 children having elective UGIE, A variety of health problems were found during the investigation, including food bolusimpact (2 %), achalasia cardia (5 %), pepticstricture (6 %), congenitalstricture (3 %), post-esophageal atresia repairanastomoticstricture (4 %), and symptoms of gastro esophageal reflux, including vomiting (10 %), regurgitation (2 %), belchingchest (1,5 %), nocturnal cough (2,5 %), pain/heartburn (12,5 %), and feeding refusal (1 %). There were several unusual illnesses that were observed, including Crohn's disease accounted for 2 %, paediatric intestinal pseudo-obstruction (10 %), abdominal discomfort (17,5 %), celiacdisease (16 %), cow's milk protein allergy (3 %), and un classified IBD (7 %).
Conclusion: EoEfrequently affects GERD patients who are recalcitrant to treatment. Dysphagia, food impaction, and heartburn are posible symptoms. EGD and esophageal biopsy should be explored for EoEscreening in elderly individuals with strong GERD who are atopy positive and who have not responded to gastric acid inhibitors.
References
Carlos, Gustavo Campanha Menon, et al. "TreatmentforEosinophilicEsophagitis in adults: Where are we?."Seven Editora (2023). doi:10.56238/devopinterscie-150
Patel, Ankit D., et al., eds. The SAGES Manual of PhysiologicEvaluation of ForegutDiseases. Springer, 2023.
Ridolo, Erminia, et al. "Assessingtheriskfactorsforrefractoryeosinophilicesophagitis in children and adults." GastroenterologyResearch and Practice 2019.1 (2019): 1654543.doi:10.1155/2019/1654543
Wilson, Bridget E., et al. "TheRelationshipBetweenEosinophilicEsophagitis and Immunotherapy." Immunology and AllergyClinics (2024). doi:10.1016/j.iac.2024.01.001
Zarzycka, Marta, et al. "Understanding of EosinophilicEsophagitis in Children-A ComprehensiveStudyonEpidemiology, ClinicalManifestations, Diagnosis and InnovativeTreatmentModalities." Journal of Education, Health and Sport 55 (2024): 137-154. doi:10.12775/JEHS.2024.55.009
Patel, Amit, and RenaYadlapati. "Diagnosis and management of refractorygastroesophagealrefluxdisease." Gastroenterology&hepatology 17.7 (2021): 305. https://doi.org/10.1016/B978-0-323-99865-9.00001-4
Yasuda, Jessica L., et al. "Pharmacogenomicsfail to explainprotonpumpinhibitorrefractoryesophagitis in pediatricesophageal atresia." Neurogastroenterology&Motility 34.1 (2022): e14217. doi:10.1111/nmo.14217
Lee, Christopher J., Timothy M. Farrell, and Evan S. Dellon. "TreatmentOutcomes of PatientsWithOverlappingEosinophilicEsophagitis and GastroesophagealRefluxDiseaseAfterAntirefluxSurgery." Foregut (2024): 26345161241237521. doi:10.1177/26345161241237521
Krishnan, Usha. "Eosinophilicesophagitis in esophageal atresia." Frontiers in pediatrics 7 (2019): 497. doi:10.3389/fped.2019.00497
Mabrouk, Mahasen Abd Alrahman, Shendy Mohammed Sherif, and Mahmoud Hassan Ali MorsyEliouny. "A StudyonEosinophilic and LymphocyticEsophagitis in PatientswithTypicalGastroesophagealRefluxDiseaseSymptoms." International Journal of HealthSciences II: 3358-3371. doi:10.53730/ijhs.v6nS2.5858
Greuter, Thomas, et al. "Effectiveness and safety of high-vs low-doseswallowedtopicalsteroidsformaintenancetreatment of eosinophilicesophagitis: a multicenterobservationalstudy." ClinicalGastroenterology and Hepatology 19.12 (2021): 2514-2523. doi:10.1016/j.cgh.2020.08.027
Hirsch, Suzanna, et al. "Characterization of eosinophilicesophagitis in infants and toddlers." Journal of PediatricGastroenterology and Nutrition 77.1 (2023): 86-92. doi:10.1097/MPG.0000000000003803
Muftah, Mayssan, et al. "Baselineperipheraleosinophilcountindependentlypredictsprotonpumpinhibitor response in eosinophilicesophagitis." Journal of ClinicalGastroenterology 58.3 (2024): 242-246. doi:10.1097/MCG.0000000000001845
Alaber, Omar, et al. "Epidemiology of eosinophilicesophagitis in patientswithcystic fibrosis: a population-based 5-year study." PediatricGastroenterology, Hepatology&Nutrition 25.4 (2022): 283. doi:10.5223%2Fpghn.2022.25.4.283
Pesce, Marcella, et al. "Isthere a role for pH impedancemonitoring in identifyingeosinophilicesophagitis in childrenwithesophageal atresia?." TheJournal of Pediatrics 210 (2019): 134-140. doi:10.1016/j.jpeds.2019.03.015
Muir, Amanda, and Gary W. Falk. "Eosinophilicesophagitis: a review." Jama 326.13 (2021): 1310-1318. doi:10.1001/jama.2021.14920
Rawy, Abeer M., Amr M. Elmistekawy, and Rabie E. Elshaer. "Studyontheassociationbetweeneosinophilicesophagitis and bronchialasthma in Egyptianpatientswithesophagealsymptoms." TheEgyptianJournal of ChestDiseases and Tuberculosis 69.2 (2020): 323-330. doi:10.4103/ejcdt.ejcdt_144_19
Ketchem, Corey J., et al. "Higherbodymassindexisassociatedwithdecreasedtreatment response to topicalsteroids in eosinophilicesophagitis." ClinicalGastroenterology and Hepatology 21.9 (2023): 2252-2259. doi:10.1016/j.cgh.2022.11.004
Abulawi, Ahmad, et al. "High-ResolutionEsophagealManometricFeatures in EosinophilicEsophagitisPatients: A RetrospectiveStudy." GastroHepAdvances 1.5 (2022): 703-708. doi:10.1016/j.gastha.2022.04.020
Menard-Katcher, Calies, and Seema Aceves. "Pathophysiology and ClinicalImpact of EsophagealRemodeling and Fibrosis in EosinophilicEsophagitis." Immunology and AllergyClinics (2024).doi:10.1016/j.iac.2023.12.002
Visaggi, Pierfrancesco, et al. "Eosinophilicesophagitis: clinical, endoscopic, histologic and therapeuticdifferences and similaritiesbetweenchildren and adults." Therapeuticadvances in gastroenterology 14 (2021): 1756284820980860. doi:10.1177/1756284820980860
Fujiwara, Yasuhiro. "Symptom-baseddiagnosticapproachforeosinophilicesophagitis." Journal of gastroenterology 55 (2020): 833-845. doi:10.1007/s00535-020-01701-y
Biedermann, Luc, et al. "Eosinophilicesophagitis—establishedfacts and new horizons." Seminars in Immunopathology. Vol. 43. No. 3. Berlin/Heidelberg: SpringerBerlin Heidelberg, 2021. doi:10.1007/s00281-021-00855-y
Grasso, Julianna, Diane RigassioRadler, and RenaZelig. "Single‐foodelimination of cow'smilk as a treatmentforeosinophilicesophagitis in childrenaged 2–18 years: A review of theliterature." Nutrition in ClinicalPractice (2024). doi:10.1002/ncp.11117
Rothenberg, Marc E., et al. "Impressions and aspirationsfromthe FDA GREAT VI workshop oneosinophilic gastrointestinal disordersbeyondeosinophilicesophagitis and perspectivesforprogress in thefield." Journal of Allergy and ClinicalImmunology 149.3 (2022): 844-853. doi:10.1016/j.jaci.2021.12.768.
Published
Issue
Section
License
Copyright (c) 2024 Nithesh Babu Ramesh, Prasanna venkatesh, Tusha, Neha Nanditha Adepu, Abinaya Srinivasa Rangan, Shubhansh Bansal (Author)
This work is licensed under a Creative Commons Attribution 4.0 International License.
The article is distributed under the Creative Commons Attribution 4.0 License. Unless otherwise stated, associated published material is distributed under the same licence.
