Molecular approach to skin aging: new perspectives

Authors

DOI:

https://doi.org/10.56294/saludcyt2024763

Keywords:

Skin Aging, Cellular Senescence, Extrinsic Aging, Intrinsic Aging

Abstract

Introduction: skin aging is a physiological process that causes concern in people by modifying the morphological characteristics of the skin; Beyond aesthetics, the skin is an organ with various functions, such as protection, hormone secretion, temperature regulation; Aging can be of two types: intrinsic, produced by the senescence of cells, extrinsic: produced by the interaction of all the components of the skin and external factors, the best known being ultraviolet (UV) rays from the sun.
Objectives: a bibliographic review of the histophysiology of the skin and its aging was carried out, to describe updated scientific evidence on the etiopathogenesis and treatment of skin aging.
Methods: this bibliographic review was carried out through a literature search through databases such as: Pubmed, NIH/PMC, Springer, Google Scholar; that have been published in the period 2019 to 2023.
Conclusions: skin aging is a process that we will all suffer from, however, exposure to external factors such as UV rays accelerate it by increasing the secretory pattern which in turn increases the presence of metalloproteinases. There are no key studies that demonstrate the effectiveness of any treatment that completely stops this process

References

1. WOJCIECH P. ROSS: HISTOLOGIA TEXTO Y ATLAS CORRELACIÓN CON BIOLOGÍA MOLECULAR Y CELULAR. In: LIPPINCOTT WILLIAMS AND WILKINS., editor. Octava edi. Wolters Kluwer; 2020. p. 1036.

2. Wong QYA, Chew FT. Defining skin aging and its risk factors: a systematic review and meta-analysis. Sci Reports 2021 111 [Internet]. 2021 Nov 11 [cited 2023 Nov 11];11(1):1–13. Available from: https://www.nature.com/articles/s41598-021-01573-z

3. Boismal F, Serror K, Dobos G, Zuelgaray E, Bensussan A, Michel L. Skin aging: Pathophysiology and innovative therapies. Medecine/Sciences [Internet]. 2020 Dec 1 [cited 2023 Jun 19];36(12):1163–72. Available from: https://pubmed.ncbi.nlm.nih.gov/33296633/

4. Shin JW, Kwon SH, Choi JY, Na JI, Huh CH, Choi HR, et al. Molecular Mechanisms of Dermal Aging and Antiaging Approaches. Int J Mol Sci [Internet]. 2019 May 1 [cited 2023 Nov 11];20(9). Available from: /pmc/articles/PMC6540032/

5. Khmaladze I, Leonardi M, Fabre S, Messaraa C, Mavon A. The Skin Interactome: A Holistic “Genome-Microbiome-Exposome” Approach to Understand and Modulate Skin Health and Aging. Clin Cosmet Investig Dermatol [Internet]. 2020 [cited 2023 Nov 11];13:1021. Available from: /pmc/articles/PMC7769076/

6. Krutmann J, Schikowski T, Morita A, Berneburg M. Environmentally-Induced (Extrinsic) Skin Aging: Exposomal Factors and Underlying Mechanisms. J Invest Dermatol [Internet]. 2021 Apr 1 [cited 2023 Nov 11];141(4):1096–103. Available from: http://www.jidonline.org/article/S0022202X20324088/fulltext

7. Lee YI, Choi S, Roh WS, Lee JH, Kim TG. Cellular Senescence and Inflammaging in the Skin Microenvironment. Int J Mol Sci [Internet]. 2021 Apr 2 [cited 2023 Nov 11];22(8). Available from: /pmc/articles/PMC8068194/

8. Fitsiou E, Pulido T, Campisi J, Alimirah F, Demaria M. Cellular Senescence and the Senescence-Associated Secretory Phenotype as Drivers of Skin Photoaging. J Invest Dermatol [Internet]. 2021 Apr 1 [cited 2023 Nov 11];141(4):1119–26. Available from: http://www.jidonline.org/article/S0022202X20322843/fulltext

9. Parisi M, Verrillo M, Luciano MA, Caiazzo G, Quaranta M, Scognamiglio F, et al. Use of Natural Agents and Agrifood Wastes for the Treatment of Skin Photoaging. Plants [Internet]. 2023 Feb 1 [cited 2023 Nov 11];12(4). Available from: /pmc/articles/PMC9966275/

10. Ye L, Mauro TM, Dang E, Wang G, Hu LZ, Yu C, et al. Topical Applications of an Emollient Reduce CirculatingPro-Inflammatory Cytokine Levels in Chronically Aged Humans: A Pilot ClinicalStudy. J Eur Acad Dermatol Venereol [Internet]. 2019 Nov 1 [cited 2023 Nov 11];33(11):2197. Available from: /pmc/articles/PMC6728229/

11. Domaszewska-Szostek A, Puzianowska-Kuźnicka M, Kuryłowicz A. Flavonoids in Skin Senescence Prevention and Treatment. Int J Mol Sci [Internet]. 2021 Jul 1 [cited 2023 Nov 11];22(13):6814. Available from: /pmc/articles/PMC8267725/

12. de Miranda RB, Weimer P, Rossi RC. Effects of hydrolyzed collagen supplementation on skin aging: a systematic review and meta-analysis. Int J Dermatol [Internet]. 2021 Dec 1 [cited 2023 Nov 11];60(12):1449–61. Available from: https://onlinelibrary.wiley.com/doi/full/10.1111/ijd.15518

13. Maia Campos PMBG, Franco RSB, Kakuda L, Cadioli GF, Costa GMD, Bouvret E. Oral Supplementation with Hydrolyzed Fish Cartilage Improves the Morphological and Structural Characteristics of the Skin: A Double-Blind, Placebo-Controlled Clinical Study. Mol 2021, Vol 26, Page 4880 [Internet]. 2021 Aug 12 [cited 2023 Nov 11];26(16):4880. Available from: https://www.mdpi.com/1420-3049/26/16/4880/htm

14. Pu SY, Huang YL, Pu CM, Kang YN, Hoang KD, Chen KH, et al. Effects of Oral Collagen for Skin Anti-Aging: A Systematic Review and Meta-Analysis. Nutrients [Internet]. 2023 May 1 [cited 2023 Nov 11];15(9). Available from: /pmc/articles/PMC10180699/

15. Hsu TF, Su ZR, Hsieh YH, Wang MF, Oe M, Matsuoka R, et al. Oral Hyaluronan Relieves Wrinkles and Improves Dry Skin: A 12-Week Double-Blinded, Placebo-Controlled Study. Nutrients [Internet]. 2021 Jul 1 [cited 2023 Nov 11];13(7). Available from: /pmc/articles/PMC8308347/

16. Poomanee W, Yaowiwat N, Pattarachaidaecharuch T, Leelapornpisid P. Optimized multiherbal combination and in vivo anti-skin aging potential: a randomized double blind placebo controlled study. Sci Reports 2023 131 [Internet]. 2023 Apr 6 [cited 2023 Nov 11];13(1):1–11. Available from: https://www.nature.com/articles/s41598-023-32738-7

17. Poomanee W, Khunkitti W, Chaiyana W, Intasai N, Lin WC, Lue SC, et al. Multifunctional biological properties and phytochemical constituents of Mangifera indica L. seed kernel extract for preventing skin aging. Toxicol Res [Internet]. 2021 Oct 1 [cited 2023 Nov 11];37(4):459. Available from: /pmc/articles/PMC8476666/

18. Hughes MCB, Williams GM, Pageon H, Fourtanier A, Green AC. Dietary Antioxidant Capacity and Skin Photoaging: A 15-Year Longitudinal Study. J Invest Dermatol. 2021 Apr 1;141(4):1111-1118.e2.

19. Mekić S, Jacobs LC, Hamer MA, Ikram MA, Schoufour JD, Gunn DA, et al. A healthy diet in women is associated with less facial wrinkles in a large Dutch population-based cohort. J Am Acad Dermatol. 2019 May 1;80(5):1358-1363.e2.

20. Solá P, Mereu E, Bonjoch J, Casado-Peláez M, Prats N, Aguilera M, et al. Targeting lymphoid-derived IL-17 signaling to delay skin aging. Nat Aging 2023 36 [Internet]. 2023 Jun 8 [cited 2023 Nov 11];3(6):688–704. Available from: https://www.nature.com/articles/s43587-023-00431-z

21. Zhou X, Cao Q, Orfila C, Zhao J, Zhang L. Systematic Review and Meta-Analysis on the Effects of Astaxanthin on Human Skin Ageing. Nutrients [Internet]. 2021 Sep 1 [cited 2023 Nov 11];13(9). Available from: /pmc/articles/PMC8472736/

22. Lim HY, Jeong D, Park SH, Shin KK, Hong YH, Kim E, et al. Antiwrinkle and Antimelanogenesis Effects of Tyndallized Lactobacillus acidophilus KCCM12625P. Int J Mol Sci [Internet]. 2020 Mar 1 [cited 2023 Nov 11];21(5). Available from: /pmc/articles/PMC7084287/

23. Galadari H, Galadari I, Smit R, Prygova I, Redaelli A. Use of AbobotulinumtoxinA for Cosmetic Treatments in the Neck, and Middle and Lower Areas of the Face: A Systematic Review. Toxins (Basel) [Internet]. 2021 Feb 1 [cited 2023 Nov 11];13(2). Available from: /pmc/articles/PMC7926328/

24. Dhaliwal S, Rybak I, Pourang A, Burney W, Haas K, Sandhu S, et al. Randomized double-blind vehicle controlled study of the effects of topical acetyl zingerone on photoaging. J Cosmet Dermatol [Internet]. 2021 Jan 1 [cited 2023 Nov 11];20(1):166–73. Available from: https://onlinelibrary.wiley.com/doi/full/10.1111/jocd.13464

25. Meyer TA, Swindell WR, Chaudhuri RK. Acetyl Zingerone: A Photostable Multifunctional Skincare Ingredient That Combats Features of Intrinsic and Extrinsic Skin Aging. Antioxidants [Internet]. 2023 Jun 1 [cited 2023 Nov 11];12(6):1168. Available from: /pmc/articles/PMC10295400/

26. Tseng YP, Liu C, Chan LP, Liang CH. Coffee pulp supplement affects antioxidant status and favors anti-aging of skin in healthy subjects. J Cosmet Dermatol [Internet]. 2022 May 1 [cited 2023 Nov 11];21(5):2189–99. Available from: https://onlinelibrary.wiley.com/doi/full/10.1111/jocd.14341

27. Thompson EL, Pitcher LE, Niedernhofer LJ, Robbins PD. Targeting Cellular Senescence with Senotherapeutics: Development of New Approaches for Skin Care. Plast Reconstr Surg [Internet]. 2022 Oct 10 [cited 2023 Nov 11];150(2 4S):12S. Available from: /pmc/articles/PMC9529240/

28. Zhang L, Pitcher LE, Yousefzadeh MJ, Niedernhofer LJ, Robbins PD, Zhu Y. Cellular senescence: a key therapeutic target in aging and diseases. J Clin Invest [Internet]. 2022 Aug 8 [cited 2023 Nov 11];132(15). Available from: /pmc/articles/PMC9337830/

29. Hickson LTJ, Langhi Prata LGP, Bobart SA, Evans TK, Giorgadze N, Hashmi SK, et al. Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease. EBioMedicine. 2019 Sep 1;47:446–56.

30. Chung CL, Lawrence I, Hoffman M, Elgindi D, Nadhan K, Potnis M, et al. Topical rapamycin reduces markers of senescence and aging in human skin: an exploratory, prospective, randomized trial. GeroScience [Internet]. 2019 Dec 1 [cited 2023 Nov 11];41(6):861. Available from: /pmc/articles/PMC6925069/

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Published

2024-02-27

How to Cite

1.
Fiallos A, Batista Castro Z. Molecular approach to skin aging: new perspectives. Salud, Ciencia y Tecnología [Internet]. 2024 Feb. 27 [cited 2024 Dec. 10];4:763. Available from: https://sct.ageditor.ar/index.php/sct/article/view/857