Environmental factors associated with cleft lip and palate in children treated at the William Soler Hospital
DOI:
https://doi.org/10.56294/saludcyt2024772Keywords:
Cleft Lip, Cleft Palate, Teratogens, Abnormalities, Drug InducedAbstract
Introduction: Cleft lip and palate is the most prevalent craniofacial congenital defect worldwide. It consists of a labial or palatal cleft, even a combination of both. It is currently known that cleft lip and palate have multifactorial causes, which include both genetic and environmental factors, which influence the first trimester of pregnancy. Objective: To describe environmental factors in patients with cleft lip and palate treated at the William Soler Pediatric Hospital, in the period between 2021 and 2022. Methodological design: Descriptive, cross-sectional and retrospective study in patients with a diagnosis of cleft lip and palate. The sample was characterized taking into account sex, type of fissure, maternal toxic habits, exposure to radiation, mechanical injuries and environmental toxins, drug consumption, as well as acute and chronic maternal diseases. Data collected during interrogation and physical examination were used. Results: isolated palatal clefts represented 50,5 %. 13,7 % of mothers smoked during the first trimester of pregnancy, while 10,5 % consumed alcohol. High blood pressure (25 %) was the most common maternal chronic disease while 41 % were diagnosed with vaginal moniliasis. Conclusions: Isolated cleft palate and considerable tobacco and alcohol consumption among pregnant women predominated. Among the chronic diseases, there was a predominance of high blood pressure, the most frequent infectious diseases were vaginal moniliasis and urinary tract infections, and there was a high frequency of the consumption of clotrimazole and oral contraceptives
References
1. Shaw DW. Global strategies to reduce the health care burden of craniofacial anomalies: report of WHO meetings on international collaborative research on craniofacial anomalies. Cleft Palate Craniofac J [Internet]. 2004 [citado el 10 de diciembre de 2022]; 41(3):238–43. Disponible en: http://dx.doi.org/10.1597/03-214.1
2. Leiva N, Stange C, Ayala F, Fuentes V. Clasificación anatómica: una propuesta para categorizar las fisuras labiopalatinas. Odontol Sanmarquina [Internet]. 12 de septiembre de 2019 [citado 13 de enero de 2024]; 22(3):245-9. Disponible en: https://revistasinvestigacion.unmsm.edu.pe/index.php/odont/article/view/16717
3. Martí Cabrera E, Redondo Sedano J, Mathabathe L, Gómez Sánchez A, Delgado Muñoz MD. Fisuras orofaciales: Fisura labial y/o palatina. FMC - Form Médica Contin Aten Primaria [Internet]. 2021 [citado el 13 de enero de 2024]; 28(10):567–72. Disponible en: https://www.researchgate.net/publication/356743803_Fisuras_orofaciales_Fisura_labial_yo_palatina/citation/download. http://dx.doi.org/10.1016/j.fmc.2020.12.003
4. Borrero Zamudio DC, Gutiérrez Ricaurte SP, Izaguirre Downing DM, Otero Mendoza LM. Caracterización fenotípica de la morfología facial en un grupo de población africana con fisura labio-palatina no sindrómica. Univ Odontol [Internet]. 2010 [citado el 13 de enero de 2024];29(62):11–8. Disponible en: https://www.redalyc.org/articulo.oa?id=231216375002
5. Pérez-González A, Lavielle-Sotomayor P, Clark P, Tusie-Luna MT, Palafox D. Factores de riesgo en pacientes con fisura de labio y paladar en México. Estudio en 209 pacientes. Cir. plást. iberolatinoam. [Internet]. 2021 Dic [citado 2024 Ene 13] ; 47( 4 ): 389-394. Disponible en: http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0376-78922021000400389&lng=es. Epub 28-Mar-2022. https://dx.doi.org/10.4321/s0376-78922021000400009.
6. Ortega J, Vázquez N. Problemas de Salud Mental en Niños con Fisura Labiopalatina. Rev. iberoam. psicol. [Internet]. 26 de abril de 2020 [citado 13 de enero de 2024];13(1):127-39. Disponible en: https://reviberopsicologia.ibero.edu.co/article/view/rip.13112
7. Salari N, Darvishi N, Heydari M, Bokaee S, Darvishi F, Mohammadi M. Global prevalence of cleft palate, cleft lip and cleft palate and lip: A comprehensive systematic review and meta-analysis. J Stomatol Oral Maxillofac Surg [Internet] 2022 [citado 2023 Dic 9];123(2):110–20. Disponible en: https://pubmed.ncbi.nlm.nih.gov/34033944/ http://dx.doi.org/10.1016/j.jormas.2021.05.008
8. Aslan BI, Gülşen A, Tirank ŞB, Findikçioğlu K, Uzuner FD, Tutar H, y colaboradores. Family functions and life quality of parents of children with cleft lip and palate. J Craniofac Surg [Internet]. 2019[citado 2023 Dic 9] ;29(6):1614–8. Disponible en: https://pubmed.ncbi.nlm.nih.gov/29771834/http://dx.doi.org/10.1097/SCS.0000000000004611
9. Galeh SD, Nouri-Vaskeh M, Alipour M, Fakhim SA. Clinical and demographical characteristics of cleft lip and/or palate in the northwest of Iran: An analysis of 1500 patients. Cleft Palate Craniofac J [Internet]. 2021[citado 2024 Dic 9] ;58(10):1281–6. Disponible en: https://pubmed.ncbi.nlm.nih.gov/33380223/ http://dx.doi.org/10.1177/1055665620980633
10. Cazar Almache ME, Campos Ramírez L, Pineda Álvarez D, Guillén Guerrero P. Panorama epidemiológico de la fisura labiopalatina en Quito, Guayaquil y Cuenca. Ecuador, 2010-2018. Acta Odontol Colomb [Internet]. 2020 [citado 10 de diciembre de 2023]; 10(1): 37-46, 2020. Disponible en: https://pesquisa.bvsalud.org/portal/resource/e/biblio-1123491 http://dx.doi.org/10.15446/aoc.v10n1.82122
11. Vyas T, Gupta P, Kumar S, Gupta R, Gupta T, Singh H. Cleft of lip and palate: A review. J Family Med Prim Care [Internet]. 2020 (citado 2023 Dic 9);9(6):2621. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7491837/ http://dx.doi.org/10.4103/jfmpc.jfmpc_472_20
12. Cisneros Domínguez G, Castellanos Ortiz B, Romero García LI, Cisneros Domínguez CM. Caracterización clinicoepidemiológica de pacientes con malformaciones labiopalatinas. Medisan [Internet]. 2013 [citado el 29 de enero de 2023];17(7):1039–46. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1029-30192013000700002
13. Paucar Muñoz N, Ortega López M, Téliz Meneses M, Ramos Montiel R. Etiología, diagnóstico y tratamiento del labio, paladar y labio/paladar fisurado en neonatos y lactantes. Revisión de literatura. Revista Científica Especialidades Odontológicas UG [Internet]. 2023(citado 2022 Dic 9);6(1):37–55. Disponible en: http://dx.doi.org/10.53591/eoug.v6i1.1626
14. Prada Flórez AM, Eljach Sánchez GM, Caballero Barbosa V, Torres Murillo EA. Factores ambientales asociados con labio o paladar hendido no sindrómico en una población del magdalena medio colombiano. Ustasalud [Internet]. 2014 (citado 2022 Dic 9);13(1):18. Disponible en: http://revistas.ustabuca.edu.co/index.php/USTASALUD_ODONTOLOGIA/article/view/1395/1125 http://dx.doi.org/10.15332/us.v13i1.1395
15. Blanco R, Colombo A, Suazo J. Maternal obesity is a risk factor for orofacial clefts: a meta-analysis. Br J Oral Maxillofac Surg [Internet]. 2019 [citado 9 de enero de 2023];53(8):699–704. Disponible en: http://dx.doi.org/10.1016/j.bjoms.2019.05.017
16. Munger RG, Romitti PA, Daack-Hirsch S, Burns TL, Murray JC, Hanson J. Maternal alcohol use and risk of orofacial cleft birth defects. Teratology [Internet]. 1996 [citado 9 de enero de 2023];54(1):27–33. Disponible en: http://dx.doi.org/10.1002/(SICI)1096-9926(199607)54:1<27::AID-TERA4>3.0.CO;2-0
17. DeRoo LA, Wilcox AJ, Drevon CA, Lie RT. First-trimester maternal alcohol consumption and the risk of infant oral clefts in Norway: a population-based case-control study. Am J Epidemiol [Internet]. 2008 [citado 9 de enero de 2023];168(6):638–46. Disponible en: http://dx.doi.org/10.1093/aje/kwn186
18. Kummet CM, Moreno LM, Wilcox AJ, Romitti PA, DeRoo LA, Munger RG, y colaboradores. Passive smoke exposure as a risk factor for oral clefts-A large international population-based study. Am J Epidemiol [Internet]. 2016 [citado 9 de enero de 2023];183(9):834–41. Disponible en: http://dx.doi.org/10.1093/aje/kwv279
19. Little J, Cardy A, Munger RG. Tobacco smoking and oral clefts: a meta-analysis. Bull World Health Organ [Internet]. 2004 [citado el 29 de enero de 2023];82(3):213–8. Disponible en: https://pubmed.ncbi.nlm.nih.gov/15112010/
20. Pusapaz Pusapaz DE, Arturo Terranova MC, Arturo Terranova D. Genética de las fisuras labiopalatinas: una visión general de los factores de riesgo genéticos y ambientales. Rev Med [Internet]. 2022 (citado 2021 Dic 9);29(2):93–106. Disponible en: http://dx.doi.org/10.18359/rmed.5706
21. Fell M, Dack K, Chummun S, Sandy J, Wren Y, Lewis S. Maternal cigarette smoking and cleft lip and palate: A systematic review and meta-analysis. Cleft Palate Craniofac J [Internet]. 2022 (citado 2021 Dic 9);59(9):1185–200. Disponible en: http://dx.doi.org/10.1177/10556656211040015
22. Palmieri A, Avantaggiato A, Marzia Arlotti GB, Luca S, Marcella M, y colaboradores. Drugs and nonsyndromic orofacial cleft: an update. Braz J Oral Sci (internet) 2008 [citado 9 de enero de 2023]; 7: 1470-1475. Disponible en: https://doi.org/10.20396/bjos.v7i24.8642941
23. Källén B. Maternal drug use and infant cleft lip/palate with special reference to corticoids. Cleft Palate Craniofac J [Internet]. 2003 (citado 2022 Dic 9);40(6):624–8. Disponible en: http://dx.doi.org/10.1597/02-077
24. A Oner D, Tastan H. Cleft lip and palate: Epidemiology and etiology. Otorhinolaryngol Head Neck Surg [Internet]. 2020 (citado 2022 Dic 9);5(4). Disponible en: https://pdfs.semanticscholar.org/0987/cb8c98337b72cb797d86d8a925a4648f83e0.pdf
25. Liu D, Zhang C, Wu L, Zhang L, Zhang L. Fetal outcomes after maternal exposure to oral antifungal agents during pregnancy: A systematic review and meta-analysis. Int J Gynaecol Obstet [Internet]. 2020 (citado 2022 Dic 9);148(1):6–13. Disponible en: http://dx.doi.org/10.1002/ijgo.12993
26. Plasencia-Dueñas EA, Díaz-Vélez C, Dueñas-Roque MM. Factores asociados a la presencia de fisura labiopalatina en recién nacidos en un hospital peruano de tercer nivel de atención. Un estudio de casos y controles. Acta médica peru [Internet]. 2020 [citado 9 de enero de 2023];37(3). Disponible en: http://www.scielo.org.pe/pdf/amp/v37n3/1728-5917-amp-37-03-304.pdf
27. Lira Plascencia J, Delgado Gutiérrez G, Aguayo González P, Coria Soto I, Zambrana Catañeda M, Ibargüengoitia Ochoa F, y colaboradores. Edad materna avanzada y embarazo: ¿Que tanto es tanto? Ginecol obstet Méx [Internet]. 1997 [citado el 29 de enero de 2023];373–8. Disponible en: https://pesquisa.bvsalud.org/portal/resource/pt/lil-210707
28. Motta IM. Promoción de salud. la importancia de conocer los factores teratogénicos que afectan el SN. Revista Digital-Vol 3 N 2 Julio 2019 ISSN Nº 2469-0066.33. [citado 2021 Ago 12]. Disponible en: https://www.kennedy.edu.ar/wp-content/uploads/2019/10/2019_07_Revista-Prospectiva_carta.pdf#page=33
Published
Issue
Section
License
Copyright (c) 2024 Julio Valcarcel Llerandi, Estela Morales Peralta, María del Carmen Fernández González , Amparo Pérez Borrego (Author)
This work is licensed under a Creative Commons Attribution 4.0 International License.
The article is distributed under the Creative Commons Attribution 4.0 License. Unless otherwise stated, associated published material is distributed under the same licence.
