Role of vitamin d in patients with type 2 diabetes mellitus
DOI:
https://doi.org/10.56294/saludcyt2022202Keywords:
Type 2 Diabetes Mellitus, Blood Glucose, Insulin;, Insulin Resistance, Vitamin DAbstract
Introduction: Vitamin D has been considered as a protective component for type II diabetes mellitus, this is because insulin sensitivity is stimulated by insulin receptor expression and peroxisome proliferation receptor activation, which is stimulated in an indirect way on insulin secretion and is going to be regulated by calbindin.
Aim: to describe the role of vitamin D in patients with type 2 diabetes mellitus.
Methodology: it is a narrative literature review. Information was collected through databases such as: Pubmed and Scopus. Time limit 5 years, English language.
Results: Vitamin D supplementation in diabetic patients contributes to decrease insulin resistance and during the analysis of glycemic controls, a decrease in glucose and glycosylated hemoglobin was observed. As for insulin resistance, the authors relate it mostly to prediabetes, this is because through the analysis in patients and after vitamin D supplementation, it may have a preventive effect for the development of type 2 diabetes mellitus.
Conclusions: Vitamin D has some acceptance as a treatment per se for type 2 diabetes mellitus
References
1. Jódar-Gimeno E, Muñoz-Torres M. Sistema hormonal D y diabetes mellitus: lecciones de los activadores selectivos del receptor de vitamina D. Endocrinol Nutr. 2013;60(2):87–95. http://doi.org/10.1016/j.endonu.2012.04.005.
2. Pittas AG, Jorde R, Kawahara T, Dawson-Hughes B. Vitamin D Supplementation for Prevention of Type 2 Diabetes Mellitus: To D or Not to D? J Clin Endocrinol Metab. 2020;105(12):3721–33. http://doi.org/10.1210/clinem/dgaa594.
3. López Gavilanez E, Orces CH, Guerrero Franco K, Segale Bajaña A, Veliz Ortega J, Bajaña Granja W, et al. Insuficiencia de vitamina D en mujeres postmenopáusicas ecuatorianas con diabetes mellitus tipo 2. Rev Osteoporos Metab Miner. 2018;10(1):7–14. https://dx.doi.org/10.4321/s1889-836x2018000100002.
4. Naranjo EGB, Campos GFC, Fallas YMG. Estilo de vida saludable en diabetes mellitus tipo 2: beneficios en el manejo crónico. Rev Medica Sinerg. 2021;6(2):e639–e639. https://doi.org/10.31434/rms.v6i2.639
5. Zavala Calahorrano A, Fernández E. Diabetes mellitus tipo 2 en el Ecuador: revisión epidemiológica. Mediciencias UTA. 2018;2:3.
6. García-Giraldo AM, Vargas-Uricoechea H, Potosí-García JA, Santiago-Ausecha DR, García-Giraldo AM, Vargas-Uricoechea H, et al. Prevalencia de bajos niveles de vitamina D en pacientes con osteopenia y osteoporosis. Popayán, Colombia. Univ Salud. 2021;23(3):248–54. https://doi.org/10.22267/rus.212303.238.
7. Calatayud M, Jódar E, Sánchez R, Guadalix S, Hawkins F. Prevalencia de concentraciones deficientes e insuficientes de vitamina D en una población joven y sana. Endocrinol Nutr. 2009;56(4):164–9. https://doi.org/10.22267/rus.212303.238.
8. Xing Y, Cheng T, Zhou F, Ma H. The Association Between Vitamin D and Type 2 Diabetes Mellitus Complicated with Non-Alcoholic Fatty Liver Disease: An Observational Cross-Sectional Study. Diabetes Metab Syndr Obes Targets Ther 2022;15:269–80. https://doi.org/10.2147%2FDMSO.S348870.
9. López G, Barnaby O. Hipocalcemia severa por deficiencia de vitamina D en una adulta mayor. Rev Medica Hered. 2018;29(3):178–81. https://doi.org/10.20453/rmh.v29i3.3407.
10. Sánchez PZ, Herrera PA, Paredes V, Villacres A, Rueda FC. Determinación de los niveles séricos de vitamina D en los pacientes diagnosticados con Esclerosis múltiple y su relación con la severidad y el comportamiento de la enfermedad en el Hospital Metropolitano de Quito y en el Hospital Carlos Andrade Marín. Rev Médica-Científica CAMbios HECAM. 2016;15(1):52–5. https://doi.org/10.36015/cambios.v15.n1.2016.199.
11. Johny E, Jala A, Nath B, Alam MJ, Kuladhipati I, Das R, et al. Vitamin D Supplementation Modulates Platelet-Mediated Inflammation in Subjects With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Trial. Front Immunol 2022;13:869591. https://doi.org/10.3389/fimmu.2022.869591.
12. Zuluaga Espinosa NA, Alfaro Velásquez JM, Balthazar González V, Jiménez Blanco KE, Campuzano Maya G. Vitamina D: nuevos paradigmas. Medicina & Laboratorio. 2011;17(05-06):211-246.
13. Angellotti E, D’Alessio D, Dawson-Hughes B, Chu Y, Nelson J, Hu P, et al. Effect of vitamin D supplementation on cardiovascular risk in type 2 diabetes. Clin Nutr Edinb Scotl. 2019;38(5):2449–53. https://doi.org/10.1016%2Fj.clnu.2018.10.003.
14. Cojic M, Kocic R, Klisic A, Kocic G. The Effects of Vitamin D Supplementation on Metabolic and Oxidative Stress Markers in Patients With Type 2 Diabetes: A 6-Month Follow Up Randomized Controlled Study. Front Endocrinol. 2021;12:610893. https://doi.org/10.3389/fendo.2021.610893.
15. Pittas AG, Dawson-Hughes B, Sheehan P, Ware JH, Knowler WC, Aroda VR, et al. Vitamin D Supplementation and Prevention of Type 2 Diabetes. N Engl J Med. 2019 ;381(6):520–30. https://doi.org/10.1056/nejmoa1900906.
16. Mehta S, Nain P, Agrawal BK, Singh RP, Kaur J, Maity S, et al. Effectiveness of Empagliflozin With Vitamin D Supplementation in Peripheral Neuropathy in Type 2 Diabetic Patients. Cureus. 2021;13(12):e20208. https://doi.org/10.7759/cureus.20208.
17. Hoseini R, Rahim HA, Ahmed JK. Concurrent alteration in inflammatory biomarker gene expression and oxidative stress: how aerobic training and vitamin D improve T2DM. BMC Complement Med Ther. 2022;22(1):165. https://doi.org/10.1186/s12906-022-03645-7.
18. Cassity EP, Redzic M, Teager CR, Thomas DT. The effect of body composition and BMI on 25(OH)D response in vitamin D-supplemented athletes. Eur J Sport Sci 2016;16(7):773–9. https://doi.org/10.1080/17461391.2015.1125952.
19. Hoseini R, Rahim HA, Ahmed JK. Decreased inflammatory gene expression accompanies the improvement of liver enzyme and lipid profile following aerobic training and vitamin D supplementation in T2DM patients. BMC Endocr Disord. 2022;22(1):245. https://doi.org/10.1186/s12902-022-01152-x.
20. Gielen S, Adams V, Möbius-Winkler S, Linke A, Erbs S, Yu J, et al. Anti-inflammatory effects of exercise training in the skeletal muscle of patients with chronic heart failure. J Am Coll Cardiol.2003;42(5):861–8. https://doi.org/10.1080/17461391.2015.1125952.
21. Petersen AMW, Pedersen BK. The anti-inflammatory effect of exercise. J Appl Physiol Bethesda Md 1985. 2005;98(4):1154–62. https://doi.org/10.1152/japplphysiol.00164.2004.
22. Slentz CA, Bateman LA, Willis LH, Shields AT, Tanner CJ, Piner LW, et al. Effects of aerobic vs. resistance training on visceral and liver fat stores, liver enzymes, and insulin resistance by HOMA in overweight adults from STRRIDE AT/RT. Am J Physiol - Endocrinol Metab. 2011;301(5):E1033–9. https://doi.org/10.1152/ajpendo.00291.2011.
23. Hu Z, Chen J, Sun X, Wang L, Wang A. Efficacy of vitamin D supplementation on glycemic control in type 2 diabetes patients: A meta-analysis of interventional studies. Medicine (Baltimore).2019;98(14):e14970. https://doi.org/10.1097/md.0000000000014970.
24. Safarpour P, Daneshi-Maskooni M, Vafa M, Nourbakhsh M, Janani L, Maddah M, et al. Vitamin D supplementation improves SIRT1, Irisin, and glucose indices in overweight or obese type 2 diabetic patients: a double-blind randomized placebo-controlled clinical trial. BMC Fam Pract. 2020;21:26. https://doi.org/10.1186/s12875-020-1096-3.
25. Huang S, Fu J, Zhao R, Wang B, Zhang M, Li L, et al. The effect of combined supplementation with vitamin D and omega-3 fatty acids on blood glucose and blood lipid levels in patients with gestational diabetes. Ann Palliat Med. 2021;10(5):5652–8. https://doi.org/10.21037/apm-21-1018.
26. Bhatt SP, Misra A, Pandey RM, Upadhyay AD, Gulati S, Singh N. Vitamin D Supplementation in Overweight/obese Asian Indian Women with Prediabetes Reduces Glycemic Measures and Truncal Subcutaneous Fat: A 78 Weeks Randomized Placebo-Controlled Trial (PREVENT-WIN Trial). Sci Rep. 2020;10(1):220. https://doi.org/10.1038/s41598-019-56904-y.
27. Khan DM, Jamil A, Randhawa FA, Butt NF, Malik U. Efficacy of oral vitamin D on glycated haemoglobin (HbA1c) in type 2 diabetics having vitamin D deficiency - A randomized controlled trial. JPMA J Pak Med Assoc. 2018;68(5):694–7.
28. Wenclewska S, Szymczak-Pajor I, Drzewoski J, Bunk M, Śliwińska A. Vitamin D Supplementation Reduces Both Oxidative DNA Damage and Insulin Resistance in the Elderly with Metabolic Disorders. Int J Mol Sci. 2019;20(12):E2891. https://doi.org/10.3390/ijms20122891.
29. Mirhosseini N, Vatanparast H, Mazidi M, Kimball SM. Vitamin D Supplementation, Glycemic Control, and Insulin Resistance in Prediabetics: A Meta-Analysis. J Endocr Soc. 2018;2(7):687–709. https://doi.org/10.1210/js.2017-00472.
30. Grimnes G, Figenschau Y, Almås B, Jorde R. Vitamin D, Insulin Secretion, Sensitivity, and Lipids. Diabetes. 2011;60(11):2748–57. https://doi.org/10.2337/db11-0650.
31. Oosterwerff MM, Eekhoff EM, Van Schoor NM, Boeke AJP, Nanayakkara P, Meijnen R, et al. Effect of moderate-dose vitamin D supplementation on insulin sensitivity in vitamin D-deficient non-Western immigrants in the Netherlands: a randomized placebo-controlled trial. Am J Clin Nutr. 2014;100(1):152–60. https://doi.org/10.3945/ajcn.113.069260.
32. Rasouli N, Brodsky IG, Chatterjee R, Kim SH, Pratley RE, Staten MA, et al. Effects of Vitamin D Supplementation on Insulin Sensitivity and Secretion in Prediabetes. J Clin Endocrinol Metab. 2022;107(1):230–40. https://doi.org/10.1210/clinem/dgab649.
33. Lu Y, Wang Y, Sun Y, Li Y, Wang J, Zhao Y, et al. Effects of active vitamin D on insulin resistance and islet β-cell function in non-diabetic chronic kidney disease patients: a randomized controlled study. Int Urol Nephrol. 2022;54(7):1725–32. https://doi.org/10.1007/s11255-021-02968-7.
34. Zhang Q, Wu Y, Lu Y, Fei X. Role of vitamin D in risk factors of patients with type 2 diabetes mellitus. Med Clin (Barc). 2020;154(5):151–6. https://doi.org/10.1016/j.medcli.2019.04.019.
35. Li X, Liu Y, Zheng Y, Wang P, Zhang Y. The Effect of Vitamin D Supplementation on Glycemic Control in Type 2 Diabetes Patients: A Systematic Review and Meta-Analysis. Nutrients. 2018;10(3):E375. https://doi.org/10.3390/nu10030375.
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Copyright (c) 2022 Giselle Marina Flores Siranaula, Claudia Gabriela Clavijo Rosales , Carla María Taimal Sarez (Author)
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