Chronic hematologic manifestations of benzene exposure in fuel dispatchers

Authors

DOI:

https://doi.org/10.56294/saludcyt2022204

Keywords:

Benzene, Chronic Disease, Hematological Diseases, Gasoline

Abstract

Introduction: benzene is an aromatic hydrocarbon considered carcinogenic due to its high toxicity, although in recent years its exposure has decreased, however, it has not been sufficient to prevent complications. Chronic exposure in concentrations greater than or equal to 1 ppm for a period of more than 8 hours a day for 10 constant years or when exposure exceeds 10 ppm for 1 year, there is a risk of developing hematological disorders.
Objective: identify chronic hematological manifestations due to exposure to benzene in fuel dispatchers.
Methods: a narrative review was carried out, compiling information from January 2000 to November 2022 in scientific databases such as Pubmed, Environmental Pollution, Dialnet, SAGE, Taylor and Francis, Springerlink, Science Direct, Scielo; using key words. 
Results: hematological manifestations that develop after chronic exposure to benzene at any concentration include lymphoid leukemia, non-Hodgkin's lymphoma, acute myeloid leukemia, myelodysplastic syndrome, chronic myeloid leukemia, multiple myeloma, chronic myeloid leukemia and aplastic anemia.
Conclusions: there are various manifestations of chronic exposure to benzene, including chronic lymphatic leukemia, non-Hodgkin's lymphoma, acute or chronic myeloid leukemia, myelodysplastic syndrome and multiple myeloma; therefore, annual medical check-ups and the application of strategies to reduce the time of occupational exposure are recommended in order to diagnose and prevent hematological diseases, since there are currently no prevention regulations to guarantee the wellbeing of dispatchers

References

1. Lesmez-Peralta JC, Santiago-Vega SP, Contreras-Pacheco OE. Exposición ocupacional al benceno y efectos adversos en la salud de los trabajadores de las estaciones de servicio automotriz. Bases teóricas y antecedentes empiricos. Revista ESPACIOS 2020;41.

2. Chaiklieng S, Pimpasaeng C, Thapphasaraphong S. Benzene Exposure at Gasoline Stations: Health Risk Assessment. Human and Ecological Risk Assessment: An International Journal 2015;21:2213-22. https://doi.org/10.1080/10807039.2015.1044938.

3. Pacheco CFJ, Martínez MA, López MH. Eritrocitos, glóbulos blancos y plaquetas en trabajadores de una refinería expuestos a benceno, Venezuela 2018. Revista Cubana de Salud y Trabajo. 2019;20(2):65-69.

4. Teklu G, Negash M, Asefaw T, Tesfay F, Gebremariam G, Teklehaimanot G, et al. Effect of Gasoline Exposure on Hematological Parameters of Gas Station Workers in Mekelle City, Tigray Region, Northern Ethiopia. J Blood Med 2021;12:839. https://doi.org/10.2147%2FJBM.S286743.

5. Flores MS, Cedillo SQ, Caicedo RS. Medición de exposición al Benceno a través de biomarcadores en gasolinera de Guayas. Polo Conoc 2022;7(8):665-84.

6. Qian S, Han Y, Shi Y, Xu W, Zhu Y, Jiang S, et al. Benzene induces haematotoxicity by promoting deacetylation and autophagy. J Cell Mol Med 2019;23(2):1022-33. https://doi.org/10.1111/jcmm.14003.

7. Liu Y, Wang J. Benzene exposure increases the risk of non-Hodgkin’s lymphoma: a systematic review and meta-analysis of observational studies. Transl Cancer Res 2022;11(6):1750-61. https://doi.org/10.21037/tcr-22-1434.

8. Qafisheh N, Mohamed OH, Elhassan A, Ibrahim A, Hamdan M. Effects of the occupational exposure on health status among petroleum station workers, Khartoum State, Sudan. Toxicol Rep 2021;8:171. https://doi.org/10.1016/j.toxrep.2020.12.025.

9. Linet MS, Yin SN, Gilbert ES, Dores GM, Hayes RB, Vermeulen R, et al. A retrospective cohort study of cause-specific mortality and incidence of hematopoietic malignancies in Chinese benzene-exposed workers. Int J Cancer 2015;137(9):2184-97. https://doi.org/10.1002/ijc.29591.

10. Salleh N, Firdaus Yhaya M, Ghafar NA, Zuhartini N, Muslim M, Hamzah NA. Occupational-related Disease to the Toxicity of Benzene Derivatives Exposure among Working Populations : A Review. Malays J Med Health Sci 2021;17(SUPP8):2636-9346.

11. Kirkeleit J, Riise T, Bråtveit M, Moen BE. Increased risk of acute myelogenous leukemia and multiple myeloma in a historical cohort of upstream petroleum workers exposed to crude oil. Cancer Causes Control CCC 2008;19(1):13-23. https://doi.org/10.1007/s10552-007-9065-x.

12. da Poça KS, Giardini I, Silva PVB, Geraldino BR, Bellomo A, Alves JA, et al. Gasoline-station workers in Brazil: Benzene exposure; Genotoxic and immunotoxic effects. Mutat Res Genet Toxicol Environ Mutagen 2021;865. https://doi.org/10.1016/j.mrgentox.2021.503322.

13. Moro AM, Brucker N, Charão MF, Baierle M, Sauer E, Goethel G, et al. Biomonitoring of gasoline station attendants exposed to benzene: Effect of gender. Mutat Res Toxicol Environ Mutagen 2017;813:1-9. https://doi.org/10.1016/j.mrgentox.2016.11.002.

14. North CM, Rooseboom M, Kocabas NA, Schnatter AR, Faulhammer F, Williams SD. Modes of action considerations in threshold expectations for health effects of benzene. Toxicol Lett 2020;334:78-86. https://doi.org/10.1016/j.toxlet.2020.09.005.

15. Çelik A, Akbaş E. Evaluation of sister chromatid exchange and chromosomal aberration frequencies in peripheral blood lymphocytes of gasoline station attendants. Ecotoxicol Environ Saf 2005;60(1):106-12. https://doi.org/10.1016/j.ecoenv.2003.10.008.

16. Scheepers PTJ, de Werdt L, van Dael M, Anzion R, Vanoirbeek J, Duca RC, et al. Assessment of exposure of gas station attendants in Sri Lanka to benzene, toluene and xylenes. Environ Res 2019;178:108670. https://doi.org/10.1016/j.envres.2019.108670.

17. 1. Neghab M, Hosseinzadeh K, Hassanzadeah J. Hematological study of petrol station workers exposed to unleaded petrol. Toxicological & Environmental Chemistry 2014;96:951-61. https://doi.org/10.1080/02772248.2014.979828.

18. Goldstein B. Benzene exposure and leukemia. Epidemiol Camb Mass 2004;15(4):509-10. https://doi.org/10.1097/01.ede.0000129523.30311.49.

19. Beelte S, Haas R, Germing U, Jansing PJ. Paradigmenwechsel in der Beurteilung myeloischer und lymphatischer Neoplasien bei beruflicher Benzolexposition (BK-Ziffer 1303). Med Klin 2009;104(3):197-203. https://doi.org/10.1007/s00063-009-1032-8.

20. Hayes RB, Yin SN, Dosemeci M, Li GL, Wacholder S, Travis LB, et al. Benzene and the dose-related incidence of hematologic neoplasms in China. Chinese Academy of Preventive Medicine–National Cancer Institute Benzene Study Group. J Natl Cancer Inst 1997;89(14):1065-71. https://doi.org/10.1093/jnci/89.14.1065.

21. Steinmaus C, Smith AH, Jones RM, Smith MT. Meta-analysis of benzene exposure and non-Hodgkin lymphoma: biases could mask an important association. Occup Environ Med 2008;65(6):371-8. https://doi.org/10.1136/oem.2007.036913.

22. Lan Q, Zhang L, Li G, Vermeulen R, Weinberg RS, Dosemeci M, et al. Hematotoxicity in Workers Exposed to Low Levels of Benzene. Science 2004;306(5702):1774. https://doi.org/10.1126/science.1102443.

23. Qu Q, Shore R, Li G, Jin X, Chen LC, Cohen B, et al. Hematological changes among Chinese workers with a broad range of benzene exposures. Am J Ind Med 2002;42(4):275-85. https://doi.org/10.1002/ajim.10121.

24. Glass DC, Gray CN, Jolley DJ, Gibbons C, Sim MR, Fritschi L, Adams GG, Bisby JA, Manuell R. Leukemia risk associated with low-level benzene exposure. Epidemiology. 2003;14(5):569-77. https://doi.org/10.1097/01.ede.0000082001.05563.e0.

25. Ehmig Santillán S. Evaluación y control del riesgo químico por vapores orgánicos en los despachadores de combustible de una estación de servicio. Enfoque UTE 2015;6(4):113-23. https://doi.org/10.29019/enfoqueute.v6n4.82.

26. Fenga C, Gangemi S, Giambò F, Tsitsimpikou C, Golokhvast K, Tsatsakis A, et al. Low-dose occupational exposure to benzene and signal transduction pathways involved in the regulation of cellular response to oxidative stress. Life Sci 2016;147:67-70. https://doi.org/10.1016/j.lfs.2015.12.025

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Published

2022-12-30

How to Cite

1.
Quito Ochoa PY, Bojorque Bojorque LM, Márquez Torres AM, Ortiz Freire GE, Sánchez Peralta SM. Chronic hematologic manifestations of benzene exposure in fuel dispatchers. Salud, Ciencia y Tecnología [Internet]. 2022 Dec. 30 [cited 2024 Sep. 14];2:204. Available from: https://sct.ageditor.ar/index.php/sct/article/view/72