Combined effects of alcohol and lead on cerebrospinal fluid production

Authors

  • Gamal Ashirbekov Department of Pathological Anatomy, Forensic Medicine with the Course of Pathological Physiology, Kazakh-Russian Medical University, Almaty, Republic of Kazakhstan Author https://orcid.org/0000-0002-5202-2311
  • Uldana Alsherieva Department of Pathological Anatomy with the Course of Forensic Medicine, Asfendiyarov Kazakh National Medical University, Almaty, Republic of Kazakhstan Author https://orcid.org/0000-0001-7498-9876
  • Kyralai Ashirbekova Department of Therapy, Asfendiyarov Kazakh National Medical University, Almaty, Republic of Kazakhstan Author https://orcid.org/0000-0001-6248-5937
  • Tokhzhan Narymbetova Department of Human Morphology and Physiology, Khoja Akhmet Yassawi International Kazakh-Turkish University, Turkestan, Republic of Kazakhstan Author https://orcid.org/0009-0003-4759-6534
  • Nurlan Khodzhayev Department of Pathology, Khoja Akhmet Yassawi International Kazakh-Turkish University, Turkestan, Republic of Kazakhstan Author https://orcid.org/0000-0002-4447-9602

DOI:

https://doi.org/10.56294/saludcyt2024.575

Keywords:

Intracranial Pressure, Liquor, Neurology, Poisoning, Ethanol, Intoxication

Abstract

Currently, due to the development of industry, a high incidence of heavy metal salt poisoning is observed, especially in people with alcohol dependence. The study aims to investigate the combined effects of these pathogens on the central nervous system. The study demonstrates changes in intracranial pressure and cerebrospinal fluid production in isolated and combined poisoning of lead and ethanol based on experimental models on 10 and 40 days of exposure, 3 main groups were formed – the group of lead salts, ethanol, combined intoxication, after which the main indicators were measured. The effect of separate and combined action of alcohol and lead on cerebrospinal fluid production and haemodynamic indices in experimental animals was studied. It was found at 40-day intoxication indices remained above normal, systemic arterial pressure was 131.8 mmHg, and the rate of cerebrospinal fluid production was 0.073±0.002 ml/min. Combined 10-day combined action of alcohol and lead enhances their excitatory effect, which is characterised by an increase in systemic arterial pressure (to the level of 135.6 mmHg) and general psycho-somatic agitation, the rate of cerebrospinal fluid production was 0.077±0.008 ml/min. The 40-day co-exposure manifested mainly toxic effects of lead, as shown by a decrease in cerebrospinal fluid production of 0.049±0.001 ml/min, and a decrease in blood pressure to a level of 93.6 mmHg. The results of this study will make it possible to develop treatment protocols for patients with ethanol and heavy metal salt poisoning, especially in the field of anti-oedema therapy

References

1. Sabyrova М, Molchanov SN. Comparative analysis of approaches to the treatment of alcohol dependence in the use and in Republic of Kazakhstan. German Int J Modern Sci. 2021;18:38-40. DOI: 10.24412/2701-8369-2021-18-38-40.

2. Aitbaeva GМ, Dzharkimbekova GK, Akhmetov FW, Kamalov GT. Analysis of mortality in acute exogenous poisoning in Almaty division of toxicology in 17 years. Bull Kazakh Nat Med Univ. 2015;4:383-5.

3. Battakova К, Saipov А. Geography of population diseases in industrial cities of central Republic of Kazakhstan. Sci Eur. 2022;100:21-6. DOI: 10.5281/zenodo.7049675.

4. Cherednichenko VS, Cherednichenko AV, Cherednichenko AV, Zheksenbaeva AK, Madibekov AS. Heavy metal deposition through precipitation in Kazakhstan. Heliyon. 2921;7(1):e05844. DOI: 10.1016/j.heliyon.2020.e05844.

5. Batyrova G, Tlegenova Z, Kononets V, et al. Hair toxic trace elements of residents across the Caspian oil and gas region of Kazakhstan: Cross-sectional study. J Environ Res Public Health. 2022;19(18):11158. DOI: 10.3390/ijerph191811158.

6. Adams C, Perry N, Conigrave J, et al. Central markers of neuroinflammation in alcohol use disorder: A meta-analysis of neuroimaging, cerebral spinal fluid, and postmortem studies. Alcohol Clin Exp Res. 2023;47(2):197-208. DOI: 10.1111/acer.14992.

7. Hnatjuk M, Nesteruk S, Tatarchuk L, Monastyrska N. Morphometric assessment of age-related structural changes in the vessels of the microcirculatory bed of the prostate gland under conditions of ethanol intoxication. Bull Med Biol Res. 2023;17(3):8-15. DOI: 10.61751/bmbr.2706-6290.2023.3.8.

8. Ilderbayev O, Okassova A, Rakhyzhanova S, Ilderbayeva G, Zhazykbayeva L. The levels of oxidative stress in a combination of stress factors. J Med Life. 2022;15(8):927-31. DOI: 10.25122/jml-2021-0060.

9. Lukyanenko N, Lenha E, Spaska A, Klets T, Shevchenko T. Tactics for treating young children with pyelonephritis and vesicoureteral reflux associated with impaired fibrillogenesis. Mol Cell Biochem. 2023;478(3):531-8. DOI: 10.1007/s11010-022-04529-7.

10. Tamm TI, Datsenko BM, Nepomniashchiĭ VV, et al. Diagnostics and tactics of treatment in patients with acute pancreatitis complicated by jaundice syndrome. Klin Khirur. 2009;7-8:122-3.

11. Belov SG, Tamm TI, Mamontov IN, Nepomnyashchiy VV. Perforation of peptic ulcer: Nonstandard situations and nonstandard decisions. Klin Khirur. 2016;3:69–72.

12. Messina A, Concerto C, Rodolico A, Petralia A, Caraci F, Signorelli MS. Is it time for a paradigm shift in the treatment of schizophrenia? The use of inflammation-reducing and neuroprotective drugs – A review. Brain Sci. 2023;13(6):957. DOI: 10.3390/brainsci13060957.

13. Komar TV, Khmara TV, Tsyhykalo OV, Hrechko DI, Khmara AB. Features of the blood supply of some areas of the head in human fetuses. Bull Med Biol Res. 2023;15(1):10-4. DOI: 10.11603/bmbr.2706-6290.2023.1.13337.

14. Hasiuk OP. Pharmacological and morphological features and socioeconomic aspects of cannabidiol: A literature review. Int J Med Med Res. 2023;9(1):47-59. DOI: 10.61751/ijmmr.2413-6077.2023.1.47.

15. Togao M, Nakayama SMM, Ikenaka Y, et al. Bioimaging of Pb and STIM1 in mice liver, kidney and brain using Laser Ablation Inductively Coupled Plasma Mass Spectrometry (LA-ICP-MS) and immunohistochemistry. Chemosphere. 2020;238:124581. DOI: 10.1016/j.chemosphere.2019.124581.

16. Bai L, Wu Y, Wang R, et al. Prepubertal exposure to Pb alters autophagy in the brain of aging mice: A time-series based model. Brain Res Bull. 2022;189:22-33. DOI: 10.1016/j.brainresbull.2022.08.013.

17. Chen L, Liu Y, Jia P, et al. Acute lead acetate induces neurotoxicity through decreased synaptic plasticity-related protein expression and disordered dendritic formation in nerve cells. Environ Sci Pollut Res. 2022;29(39),58927-35. DOI: 10.1007/s11356-022-20051-1.

18. Latronico T, Fasano A, Fanelli M, et al. Lead exposure of rats during and after pregnancy induces anti-myelin proteolytic activity: A potential mechanism for lead-induced neurotoxicity. Toxicology. 2022;472:153179. DOI: 10.1016/j.tox.2022.153179.

19. Meyer DN, Crofts EJ, Akemann C, et al. Developmental exposure to Pb2+ induces transgenerational changes to zebrafish brain transcriptome. Chemosphere. 2020;244:125527. DOI: 10.1016/j.chemosphere.2019.125527.

20. de la Monte SM, Kril JJ. Human alcohol-related neuropathology. Acta Neuropathol. 2014;127:71-90. DOI: 10.1007/s00401-013-1233-3.

21. Nutt D, Hayes A, Fonville L, et al. Alcohol and the Brain. Nutrients. 2021;13(11):3938. DOI: 10.3390/nu13113938.

22. Behl T, Yadav HN, Sharma PL. Alcoholic neuropathy: Involvement of multifaceted signalling mechanisms. Cur Mol Pharmacol. 2021;14(1):2-10. DOI: 10.2174/1874467213666200512114943.

23. Visontay R, Rao RT, Mewton L. Alcohol use and dementia: New research directions. Cur Opinion Psych. 2021;34(2):165-70. DOI: 10.1097/yco.0000000000000679.

24. Peng B, Yang Q, Joshi RB, et al. Role of alcohol drinking in Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis. Int J Mol Sci. 2020;21(7):2316. DOI: 10.3390/ijms21072316.

25. Rangel-Barajas C, Coronel I, Zhang Y, Hernández M, & Boehm II SL. Low-level developmental lead exposure does not predispose to adult alcohol self-administration, but does increase the risk of relapsing to alcohol seeking in mice: Contrasting role of GLT1 and xCT brain expression. Neuropharmacology. 2020;181:108339. DOI: 10.1016/j.neuropharm.2020.108339.

26. Albrecht PA, Fernandez-Hubeid LE, Deza-Ponzio R, Virgolini MB. The intertwining between lead and ethanol in the model organism Caenorhabditis elegans. Front Toxicol. 2022;4:991787. DOI: 10.3389/ftox.2022.991787.

27. Du X, Zheng W, Ye Q. Rare cases of severe life-threatening lead poisoning due to accident or chronic occupational exposure to lead and manganese: Diagnosis, treatment, and prognosis. Toxicol Indust Health. 2020;36(12):951-9. DOI: 10.1177/0748233720958969

Downloads

Published

2024-09-17

How to Cite

1.
Ashirbekov G, Alsherieva U, Ashirbekova K, Narymbetova T, Khodzhayev N. Combined effects of alcohol and lead on cerebrospinal fluid production. Salud, Ciencia y Tecnología [Internet]. 2024 Sep. 17 [cited 2024 Oct. 14];4:.575. Available from: https://sct.ageditor.ar/index.php/sct/article/view/575