The Relationship Between Expression of HIF-1α and Clinical Response in Cervical Cancer Patients with Neoadjuvant Chemotherapy at Dr. Soetomo Surabaya Hospital
DOI:
https://doi.org/10.56294/saludcyt20241273Keywords:
Cervical Cancer, HIF-1α, Response to ChemotherapyAbstract
This investigation aims to analyze the relationship between expression of Hypoxia Inducible factors-1 αlfa (HIF-1α) to assess the response to neoadjuvant chemotherapy in cervical cancer patients. This research is a Quast Experimental Non-Randomized Before and After with no control design with a sample size of 30 stage IIIB cervical cancer patients by inclusion and exclusion criteria, with pretest and posttest treatment, namely biopsy for immunohistochemical examination and abdominal ultrasound to evaluate lesion diameter cervix after three cycles of chemotherapy. This study showed a decrease in HIF-1α expression before and after chemotherapy (p=0,003) and a decrease in the diameter of cervical lesions before and after chemotherapy (p=0,000). Correlation between decreased HIF-1α expression and decreased diameter of cervical lesions (p=<0,05). Response to neoadjuvant chemotherapy: 25 patients (83,3 %) showed a negative response and 5 patients (16,7 %) showed a positive response. Strong HIF-1α expression before chemotherapy gave a negative response 23 and 25 subjects with a negative response after neoadjuvant chemotherapy. This study found a relationship between high HIF-α expression before chemotherapy with a negative chemotherapy response and low HIF-1α expression after neoadjuvant chemotherapy with a positive chemotherapy response in cervical cancer patients at Dr Soetomo Hospital, Surabaya
References
1. MH. Antoni, FS. Dhabhar. “The impact of psychosocial stress and stress management onimmune responses in patients with cancer”. Cancer. 2019;125(9):1417–31.
2. SP. Arum. “Stop Kanker Serviks : Panduan Bagi Wanita untuk Mengenal, Mencegah & Mengobati”. Yogyakarta; 2015.
3. LG. Seamon. “Impact of Tumour Histology on Survival in AdvancedCervical Carcinoma: an NRG Oncology/Gynaecologic Oncology Group Study”. Br J Cancer. 2018;118(2):168–70.
4. F. Safitri. “Determinan Kejadian Kanker Serviks di Rumah Sakit Umum Daerah dr. Zainoel Abidin, Provinsi Aceh Tahun 2018. Media Litbangkes” 2018;29(1):89–98.
5. N Puspitasari, S. Endah, T. Setiowati. “Hubungan Usia, Paritas dan Usia Aktivitas Seksual Pertama Kali dengan Kejadian Kanker Serviks di Ruang Rawat Inap (Alamanda & Kemuning) RSUP dr.HasaSadikin Bandung Provinsi Jawa Barat”., Jurnal Kesehatan Kartika., 2018;11(3):47–59.
6. JW. Park, J. Bae. “Prognostic significance of positive lymph node number in early cervical cancer”., Mol Clin Oncol., 2016;4(6):1052–6.
7. E. Nurlelawati, TER. Devi, I. Sumiati. “Faktor yang Berhubungan dengan Kejadian Kanker Serviks di RS Pusat Pertamina Jakarta”., Midwife Journal., 2018;5(01):8–16.
8. R. Norazizah, N. Khofiyah, DA, Rochmaniah. “Hubungan paritas dan jenis kontrasepsidengan kejadian lesi pra-kanker serviks di yayasan kanker Kalimantan Selatan”., Jurnal Berkala Kesehatan., 2019;5(1):35–9.
9. N, Mishra. R, Dwivedi. “Cervical Cancer, Breast Cancer, Depression. Study of Depression in Womenwith Cervical and Breast Cancer”., J Evol Med Dent Sci., 2015;4(12):1936-1942.
10. JY, Lee. “Prognosis of cervical cancer in the era of concurrent chemoradiation from a nationaldatabase in Korea: A comparison between squamous cell carcinoma and adenocarcinoma”., PLoS One., 2015;10(12):1–9.
11. EJ, Jung. “Cervical adenocarcinoma has a poorer prognosis and a higher propensity for distant recurrence than squamous cell carcinoma”., International Journal of Gynecological Cancer., 2017;27(6).
12. NE, Jasa. “Determinan yang Berhubungan dengan Kejadian Kanker Serviks pada Wanita di Poli Kebidanan RSUD dr. H. Abdul Moeloek Propinsi Lampung”., Jurnal Kesehatan., 2016
13. A. Husnah, N. Kurniati. “Hubungan Paritas dan Umur dengan Kejadian Kanker Serviks di RS PKU Muhammadiyah Bantul Yogyakarta Universitas ’Aisyiyah Yogyakarta”., ; 2018.
14. D. Howell, DK. Mayer, R. Fielding, M. Eicher, IM. Verdonck-De Leeuw, C. Johansen, “Management of Cancer and Health after the Clinic Visit: A Call to Action for Self Management in Cancer Care”., Jurnal Natl Cancer Inst., 2021;113(5):523–31.
15. E. Hidayat. “Hubungan Kejadian Kanker Serviks dengan Jumlah Paritas di RSUD Dr. Moewardi Tahun 2013”. Jurnal Kedokteran dan Kesehatan Indonesia., 2013
16. A. Gadducci, ME. Guerrieri, S. Cosio, “Adenocarcinoma of the uterine cervix: Pathologic features, treatment options, clinical outcome, and prognostic variables”., Crit Rev Oncol Hematol., 2019;135:103–14.
17. H. Distinarista. “Pengalaman Survivor Cancer: Studi Fenomenologi (The experiences of the cancer survivors: A phenomenology study)”., Jurnal Keperawatan Soedirman (The Soedirman Journal ofNursing)., 2017;12(3):86–94.
18. IP. Damayanti, “Faktor-faktor yang berhubungan dengan kejadian kanker serviks di RSUD Arifin Achmad Pekanbaru Tahun 2008-2010”., Jurnal Kesehatan Komunitas., 2013;2(2).
19. K. Balamurugan K, “HIF-1 at the crossroads of hypoxia, inflammation, and cancer HIF-1 at the crossroads of hypoxia, inflammation, and cancer inflammation”., Int J Cancer., 2015;138(5):1058–66.
20. F. Asyifa. “Hubungan antara Paritas dan Tingkat Pendidikan terhadap Kejadian Kanker Serviks”. 2019. 1–15 p.
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