Prognostic efficacy of platelet/lymphocyte ratio and neutrophil/lymphocyte ratio in patients with gastric cancer
DOI:
https://doi.org/10.56294/saludcyt2023232Keywords:
NLR, PLR, Gastric Cancer, Inflammation, PrognosticAbstract
Cancer is the main cause of death before age 70. Gastric cancer (GC) is responsible for 1 in 13 deaths worldwide and is predominant in men. Inflammation is closely related to cancer, as it activates different blood cells such as neutrophils, lymphocytes, platelets, etc. A bibliographic review was carried out to collect and analyze studies concerning the prognostic efficacy of neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) in patients with gastric cancer. Upon analysis, several studies indicated that elevated values of both NLR and PLR show poor prognosis. However, we suggest that more research is needed to obtain cutoff values according to GC staging, in order to be a helpful tool in GC diagnosis and prognosis
References
1. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer Journal for Clinicians 2021;71(3):209–49 https://doi.org/10.3322/caac.21660
2. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians 2018 12;68(6):394–424. https://doi.org/10.3322/caac.21492
3. Warsinggih, Syarifuddin E, Marhamah, Lusikooy RE, Labeda I, Sampetoding S, et al. Association of clinicopathological features and gastric cancer incidence in a single institution. Asian Journal of Surgery 2022;45(1):246–9. https://doi.org/10.1016/j.asjsur.2021.05.004
4. Ahorro Aaron P, El-Serag Hashem B. Burden of Gastric Cancer. Clinical Gastroenterology and Hepatology 2020;18:534–542 https://doi.org/10.1016/j.cgh.2019.07.045
5. Matsuoka T, Yashiro M. Biomarkers of gastric cancer: Current topics and future perspective. World journal of gastroenterology 2018;24(26):2818–32. https://doi.org/10.3748/wjg.v24.i26.2818
6. Donate-Moreno MJ, Lorenzo-Sánchez MV, Díaz de Mera-Sánchez Migallón I, Herraiz-Raya L, Esper-Rueda JA, Legido-Gómez O, et al. Marcadores inflamatorios como factor pronóstico en el cáncer de próstata resistente a la castración metastásico. Actas Urológicas Españolas 2020;44(10):692–700. https://doi.org/10.1016/j.acuro.2020.08.001
7. Wu D, Zhang P, Ma J, Xu J, Yang L, Xu W, et al. Serum biomarker panels for the diagnosis of gastric cancer. Cancer Medicine 2019;8(4):1576–83. https://doi.org/10.1002/cam4.2055
8. Chandrasekaran, D., Sundaram, S, Maheshkumar, K, Kathiresan, N., Padmavathi, R. Preoperative neutrophil–lymphocyte ratio/platelet–lymphocyte ratio: A potential and economical marker for renal cell carcinoma. J Can Res Ther 2022; 18:1635-9. https://doi.org/10.4103/jcrt.JCRT_482_20
9. Assad DX, Mascarenhas ECP, Normando AGC, Chardin H, Barra GB, Pratesi R, et al. Correlation between salivary and serum CA15-3 concentrations in patients with breast cancer. Molecular and Clinical Oncology 2020;13(2):155–61. https://doi.org/10.3892/mco.2020.2062
10. Kim N, Chun D, Kim S, Kim N, Baik S, Hong J, et al. Prognostic Value of Systemic Inflammatory Indices, NLR, PLR, and MPV, for Predicting 1-Year Survival of Patients Undergoing Cytoreductive Surgery with HIPEC. Journal of Clinical Medicine. 2019 Apr 29;8(5):589. https://doi.org/10.3390/jcm8050589
11. Fang T, Wang Y, Yin X, Zhai Z, Zhang Y, Yang Y, et al. Diagnostic Sensitivity of NLR and PLR in Early Diagnosis of Gastric Cancer. Journal of Immunology Research 2020;e9146042. https://doi.org/10.1155/2020/9146042
12. Hao S-J, Wan Y, Xia Y-Q, Zou X, Zheng S-Y. Size-based separation methods of circulating tumor cells. Advanced Drug Delivery Reviews. 2018;125:3–20. https://doi.org/10.1016/j.addr.2018.01.002
13. Butcher EC, Picker LJ. Lymphocyte Homing and Homeostasis. Science 1996;272:60–7. https://doi.org/10.1126/science.272.5258.60
14. Huang Z, Liu Y, Yang C, Li X, Pan C, Rao J, et al. Combined neutrophil/platelet/lymphocyte/differentiation score predicts chemosensitivity in advanced gastric cancer. BMC Cancer 2018;18:515. https://doi.org/10.1186/s12885-018-4414-6
15. Aksoy EK, Kantarcı S, Torgutalp M, Akpınar MY, Sapmaz FP, Yalçın GŞ, et al. The importance of complete blood count parameters in the screening of gastric cancer. Przeglad Gastroenterologiczny 2019;14(3):183–7. https://doi.org/10.5114/pg.2019.88167
16. Kim SG, Eom BW, Yoon H, Kim Y-W, Ryu KW. Prognostic Value of Preoperative Systemic Inflammatory Parameters in Advanced Gastric Cancer. Journal of Clinical Medicine 2022;11(18):5318. https://doi.org/10.3390/jcm11185318
17. Wang W, Tong Y, Sun S, Tan Y, Shan Z, Sun F, et al. Predictive value of NLR and PLR in response to preoperative chemotherapy and prognosis in locally advanced gastric cancer. Front Oncol 2022; 12: 936206. https://doi.org/10.3389/fonc.2022.936206
18. Wang H, Ding Y, Li N, Wu L, Gao Y, Xiao C, et al. Prognostic Value of Neutrophil–Lymphocyte Ratio, Platelet–Lymphocyte Ratio, and Combined Neutrophil–Lymphocyte Ratio and Platelet–Lymphocyte Ratio in Stage IV Advanced Gastric Cancer. Front Oncol 2020;10 https://doi.org/10.3389/fonc.2020.00841
19. Gu L, Wang M, Cui X, Mo J, Yuan L, Mao F, et al. Clinical significance of peripheral blood-derived inflammation markers in advanced gastric cancer after radical resection. BMC Surgery 2020;20(1). https://doi.org/10.1186/s12893-020-00884-8
20. Zhao G, Liu N, Wang S, Guo J, Song X, Qi Y, et al. Prognostic significance of the neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio in patients with metastatic gastric cancer. Medicine 2020;99(10):e19405. https://doi.org/10.1097/MD.0000000000019405
21. Zhang Y, Lu J-J, Du Y-P, Feng C-X, Wang L-Q, Chen M-B. Prognostic value of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in gastric cancer. Medicine 2018;97(12):e0144. https://doi.org/10.1097/MD.0000000000010144
22. Liu Z, Ge H, Miao Z, Shao S, Shi H, Dong C. Dynamic Changes in the Systemic Inflammation Response Index Predict the Outcome of Resectable Gastric Cancer Patients. Front Oncol 2021;11. https://doi.org/10.3389/fonc.2021.577043
23. Pan Y-C, Jia Z-F, Cao D-H, Wu Y-H, Jiang J, Wen S-M, et al. Preoperative lymphocyte-to-monocyte ratio (LMR) could independently predict overall survival of resectable gastric cancer patients. Medicine 2018;97(52):e13896. https://doi.org/10.1097/MD.0000000000013896
24. Giese MA, Hind LE, Huttenlocher A. Neutrophil plasticity in the tumor microenvironment. Blood 2019;133(20):2159-2167. https://doi.org/10.1182/blood2018-11-844548
25. Sun Q-Y, Zhou H-H, Mao X-Y. Emerging Roles of 5-Lipoxygenase Phosphorylation in Inflammation and Cell Death. Oxidative Medicine and Cellular Longevity 2019;e2749173. https://doi.org/10.1155/2019/2749173
26. Liang W, Li Q, Ferrara N. Metastatic growth instructed by neutrophil-derived transferrin. Proceedings of the National Academy of Sciences 2018;115(43):11060–5. https://doi.org/10.1073/pnas.1811717115
27. Schlesinger M. Role of platelets and platelet receptors in cancer metastasis. Journal of Hematology & Oncology 2018;11(1). https://doi.org/10.1186/s13045-018-0669-2
28. Yu P-C, Long D, Liao C-C, Zhang S. Association between density of tumorinfiltrating lymphocytes and prognoses of patients with gastric cancer. Medicine 2018;97(27):e11387. https://doi.org/10.1097/MD.0000000000011387
29. Lee JS, Won HS, Sun DS, Hong JH, Ko YH. Prognostic role of tumor-infiltrating lymphocytes in gastric cancer. Medicine 2018;97(32):e11769. https://doi.org/10.1097/MD.0000000000011769
30. Yumo X, Lishuo S, Xiaosheng H, Yanxin L. Gastrointestinal cancers in China, the USA, and Europe. Gastroenterology Report 2021;9(2):91-104. https://doi.org/10.1093/gastro/goab010
Published
Issue
Section
License
Copyright (c) 2023 Daniela Alexandra Rosero Freire, Joselyn Macarena López Altamirano (Author)

This work is licensed under a Creative Commons Attribution 4.0 International License.
The article is distributed under the Creative Commons Attribution 4.0 License. Unless otherwise stated, associated published material is distributed under the same licence.