A Comprehensive Review of the Pathogenesis and Virulence Factors of E. coli

Authors

DOI:

https://doi.org/10.56294/saludcyt2023411

Keywords:

Pathogenic Enteric E. Coli, E. Coli Pathotypes, Genes for Virulence Factors

Abstract

Escherichia coli are very adaptable microbes that play a significant role in the typical gut microbiota of both humans and animals. This non-pathogenic commensal bacterium has the ability to acquire a variety of mobile genetic components that are comprehensive and include genes for virulence factors is a newly discovered human pathogen that may cause a wide range of extraintestinal and gastrointestinal illnesses. Nine distinct enteric E. coli pathotypes, which range from different gastrointestinal illnesses to infections of the urinary tract, have been thoroughly characterised. These collaboration use a variety of virulence factors and effectors that regulate their transmission and pathogenicity by disrupting the functioning of host cells. This article highlights recent advances in our knowledge of the many viruses linked to the genes that distinct external ecological of gastric harmful E. coli employ to trigger extraintestinal and digestive issues in people

References

1. Pakbin B, Brück WM, Rossen JW. Virulence factors of enteric pathogenic Escherichia coli: A review. Int J Mol Sci. 2021;22(18):9922.

2. Kaper JB. Enterohemorrhagic Escherichia coli. Curr Opin Microbiol. 2020;1(1):103-108.

3. Fatima R, Aziz M. Enterohemorrhagic Escherichia Coli (EHEC). StatPearls [Internet]. 2020.

4. Yang SY, Yoon KS. Quantitative Microbial Risk Assessment of Listeria monocytogenes and Enterohemorrhagic Escherichia coli in Yogurt. Foods. 2022;11(7):971.

5. Cho SH, Lee KM, Kim CH, Kim SS. Construction of a lectin–glycan interaction network from enterohemorrhagic Escherichia coli strains by multi-omics analysis. Int J Mol Sci. 2020;21(8):2681.

6. Huerta-Saquero A, Chapartegui-González I, Bowser S, Khakhum N, Stockton JL, Torres AG. P22-Based Nanovaccines against Enterohemorrhagic Escherichia coli. Microbiol Spectrum. 2023;e04734-22.

7. Aditya A, Rahaman SO, Biswas D. Impact of Lactobacillus-originated metabolites on enterohemorrhagic E. coli in rumen fluid. FEMS Microbiol Ecol. 2022;98(12):fiac128.

8. Desvaux M, Dalmasso G, Beyrouthy R, Barnich N, Delmas J, Bonnet R. Pathogenicity factors of genomic islands in intestinal and extraintestinal Escherichia coli. Front Microbiol. 2020;11:2065.

9. Yekani M, Baghi HB, Naghili B, Vahed SZ, Sóki J, Memar MY. To resist and persist: Important factors in the pathogenesis of Bacteroides fragilis. Microb Pathog. 2020;149:104506.

10. Saeedi M, Khezri K, Seyed Zakaryaei A, Mohammadamini H. A comprehensive review of the therapeutic potential of α‐arbutin. Phytother Res. 2021;35(8):4136-4154.

11. Tosif MM, Najda A, Bains A, Kaushik R, Dhull SB, Chawla P, et al. A comprehensive review on plant-derived mucilage: Characterization, functional properties, applications, and its utilization for nanocarrier fabrication. Polymers. 2021;13(7):1066.

12. Kathayat D, Lokesh D, Ranjit S, Rajashekara G. Avian pathogenic Escherichia coli (APEC): an overview of virulence and pathogenesis factors, zoonotic potential, and control strategies. Pathogens. 2021;10(4):467.

13. Schuetz AN. Emerging agents of gastroenteritis: Aeromonas, Plesiomonas, and the diarrheagenic pathotypes of Escherichia coli. Semin Diagn Pathol. 2019;36(3):187-192.

14. Kim JS, Lee MS, Kim JH. Recent updates on outbreaks of Shiga toxin-producing Escherichia coli and its potential reservoirs. Front Cell Infect Microbiol. 2020;10:273.

15. Wang Y, Fu K. Genotoxins: The Mechanistic Links between Escherichia coli and Colorectal Cancer. Cancers. 2023;15(4):1152.

16. Amaretti A, Righini L, Candeliere F, Musmeci E, Bonvicini F, Gentilomi GA, et al. Antibiotic resistance, virulence factors, phenotyping, and genotyping of non-Escherichia coli Enterobacterales from the gut microbiota of healthy subjects. Int J Mol Sci. 2020;21(5):1847

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Published

2023-01-01

How to Cite

1.
Kademane A, Dixit M, Vasundhara. A Comprehensive Review of the Pathogenesis and Virulence Factors of E. coli. Salud, Ciencia y Tecnología [Internet]. 2023 Jan. 1 [cited 2025 Jun. 22];3:411. Available from: https://sct.ageditor.ar/index.php/sct/article/view/408