Carbapenem-resistant Klebsiella pneumoniae in nosocomial infections, a review in Latin America
DOI:
https://doi.org/10.56294/saludcyt2023478Keywords:
Klebsiella pneumoniae, Carbapenem-resistant Enterobacteriaceae, Imipenem, Meropenem, Clinical EpidemiologyAbstract
Objective: this study aimed to determine the presence of carbapenem-resistant Klebsiella pneumoniae in nosocomial infections in Latin America and to analyze its frequency and tendency in Latin America.
Methods: this study is a literature review; it was carried out through exhaustive research in different databases, Analytical and descriptive cohort studies, meta-analysis, and some clinical trials related to the presence of nosocomial infections caused by carbapenem-resistant K. pneumoniae and the genes responsible for this resistance were included.
Results: twenty-two articles were selected from different databases from Latin American countries; In addition, the percentages of resistance to carbapenems in K. pneumoniae in these countries and its trend before and during the COVID-19 pandemic were identified.
Conclusions: resistance to carbapenems in K. pneumoniae was determined as a public health problem in Latin America, considered a limiting factor in treating patients with infections caused by Enterobacter. In addition, it was identified that KPC is the main gene responsible for carbapenem resistance
References
1. Raro OHF, da Silva RMC, Filho EMR, Sukiennik TCT, Stadnik C, Dias CAG, et al. Carbapenemase-Producing Klebsiella pneumoniae From Transplanted Patients in Brazil: Phylogeny, Resistome, Virulome and Mobile Genetic Elements Harboring bla KPC- 2 or bla NDM1. Front Microbiol. 2020. https://doi.org/10.3389/fmicb.2020.01563
2. Murray P, Roshental K, Pfaller M. Microbiología médica. Vol. 7. 2013. 109–350 p.
3. Reyes JA, Melano R, Cárdenas PA, Trueba G. Mobile genetic elements associated with carbapenemase genes in South American Enterobacterales. Braz J Infect Dis. 2020 May 1; 24(3):231–238. https://doi.org/10.1016/j.bjid.2020.03.002
4. Universidad Autónoma de Coahuila Facultad de Medicina Unidad Torreón. Mecanismos De Resistencia Intrínseca y Adquirida a Antibióticos En Bacterias. Revista Medicina de Torreón. 2016;8(2).
5. Clinical and Laboratory Standards Institute (CLSI). M100 PERFORMANCE STANDARDS FOR ANTIMICROBIAL SUSCEPTIBILITY TESTING. Vol. 33. CLSI; 2023.
6. Gómez BJP, Pazmiño JPR, Quinde GSG, Viejó JFG, Amaguaña MJM, Neira ÉIR, et al. Multidrug-Resistant Klebsiella pneumoniae in a Patient with SARS-Cov-2 Pneumonia in an Intensive Care Unit in Guayaquil, Ecuador: A Case Report. Am J Med Case Rep. 2022;23. https://doi.org/10.12659/AJCR.936498
7. Pan American Health Organization. Epidemiological Alert Emergence and increase of new combinations of carbapenemases in Enterobacterales in Latin America and the Caribbean. Rev Panam Salud Publica. 2021. http://www.paho.org
8. Organización Panamericana de la Salud. Guía para el uso correcto de los equipos automatizados para identificación bacteriana y su correspondiente prueba de susceptibilidad. 2011. 5–35 p.
9. Organización Panamericana de la Salud. Resistance percentages for selected pathogens [Internet]. https://www3.paho.org/data/index.php/en/mnu-topics/antimicrobial-resistance/571-amr-vig-en.html
10. Organización Panamericana de la Salud. Alerta Epidemiológica: Emergencia e incremento. Rev Panam Salud Publica. 2021;1–8.
11. Nicola F, Cejas D, González-Espinosa F, Relloso S, Herrera F, Bonvehí P, et al. Outbreak of Klebsiella pneumoniae ST11 Resistant To Ceftazidime-Avibactam Producing KPC-31 and the Novel Variant KPC-115 during COVID-19 Pandemic in Argentina. Microbiol Spectr. 2022;10(6). https://doi.org/10.1128/spectrum.03733-22
12. Rodrigues YC, Lobato ARF, Quaresma AJPG, Guerra LMGD, Brasiliense DM. The Spread of NDM-1 and NDM-7-Producing Klebsiella pneumoniae Is Driven by Multiclonal Expansion of High-Risk Clones in Healthcare Institutions in the State of Pará, Brazilian Amazon Region. Antibiotics (Basel). 2021;10(12). https://doi.org/10.3390/antibiotics10121527
13. Quezada-Aguiluz M, Opazo-Capurro A, Lincopan N, Esposito F, Fuga B, Mella-Montecino S, et al. Novel Megaplasmid Driving NDM-1-Mediated Carbapenem Resistance in Klebsiella pneumoniae ST1588 in South America. Antibiotics (Basel). 2022 Sep 1; 11(9). https://doi.org/10.3390/antibiotics11091207
14. Remolina G. SA, Conde M. CE, Escobar C. JC, Leal C. AL, Bravo O. JS, Saavedra R. SY, et al. Carbapenemases produced in Klebsiella spp., and Pseudomonas aeruginosa in six hospitals in Bogotá - Colombia. Rev Chilena Infectol. 2021; 38(5):720–723. https://doi.org/10.4067/s0716-10182021000500720
15. Guerra-Sarmiento M, Ruíz-Martin-Leyes F, Arzuza-Ortega L, Maestre-Serrano R, Guerra-Sarmiento M, Ruíz-Martin-Leyes F, et al. Caracterización de bacilos gramnegativos multi-resistentes, aislados en pacientes hospitalizados en instituciones de salud de Barranquilla (Colombia). Rev Chilena Infectol. 2021; 38(2):189–196. https://doi.org/10.4067/S0716-10182021000200189
16. Aquino-Andrade A, Merida-Vieyra J, Arias De La Garza E, Arzate-Barbosa P, De Colsa Ranero A. Carbapenemase-producing Enterobacteriaceae in Mexico: report of seven non-clonal cases in a pediatric hospital. BMC microbiol. 2018;18(1):38. https://doi.org/10.1186/s12866-018-1166-z
17. Toledano-Tableros JE, Gayosso-Vázquez C, Jarillo-Quijada MD, Fernández-Vázquez JL, Morfin-Otero R, Rodríguez-Noriega E, et al. Dissemination of bla NDM- 1 Gene Among Several Klebsiella pneumoniae Sequence Types in Mexico Associated With Horizontal Transfer Mediated by IncF-Like Plasmids. Front Microbiol. 2021;12. https://doi.org/10.3389/fmicb.2021.611274
18. Instituto Nacional de Investigación en Salud Pública. Centro de Referencia Nacional de Resistencia a los Antimicrobianos Resumen Ejecutivo. 2022.
19. Angles-Yanqui E, Huaringa-Marcelo J, Sacsaquispe-Contreras R, Pampa-Espinoza L. Panorama of carbapenemases in Peru. Rev Panam Salud Publica. 2020;44(1):61. https://doi.org/10.26633/RPSP.2020.61
20. Carrasco-Anabalón S, Vera-Leiva A, Quezada-Aguiluz M, Morales-Rivera MF, Lima CA, Fernández J, et al. Genetic Platforms of blaCTX-M in Carbapenemase-Producing Strains of K. pneumoniae Isolated in Chile. Front Microbiol. 2018;9:324. https://doi.org/10.3389/fmicb.2018.00324
21. Villegas MV, Pallares CJ, Escandón-Vargas K, Hernández-Gómez C, Correa A, Álvarez C, et al. Characterization and Clinical Impact of Bloodstream Infection Caused by Carbapenemase-Producing Enterobacteriaceae in Seven Latin American Countries. PLoS One. 2016;11(4). https://doi.org/10.1371/journal.pone.0154092
22. Pitout JDD, Peirano G, Kock MM, Strydom KA, Matsumura Y. The Global Ascendency of OXA-48-Type Carbapenemases. Clin Microbiol Rev. 2019;33(1). https://doi.org/10.1128/CMR.00102-19
23. Salazar C, Antelo V, Vieytes M, Dávila C, Grill F, Galiana A, et al. First detection and origin of multi-drug resistant Klebsiella pneumoniae ST15 harboring OXA-48 in South America. J Glob Antimicrob Resist. 2022 Sep 1; 30:480–484. https://doi.org/10.1016/j.jgar.2022.08.005
24. Villacís JE, Reyes JA, Castelán-Sánchez HG, Dávila-Ramos S, Lazo MA, Wali A, et al. microorganisms OXA-48 Carbapenemase in Klebsiella pneumoniae Sequence Type 307 in Ecuador. Microorganisms journal. 2020; 8(435). https://doi.org/10.3390/microorganisms8030435
25. Vásquez-Ponce F, Dantas K, Becerra J, Melocco G, Esposito F, Cardoso B, et al. Detecting KPC-2 and NDM-1 Coexpression in Klebsiella pneumoniae Complex from Human and Animal Hosts in South America. Microbiol Spectr. 2022;10(5). https://doi.org/10.1128/spectrum.01159-22
26. Bocanegra-Ibarias P, Camacho-Ortiz A, Garza-González E, Flores-Treviño S, Kim H, Perez-Alba E. Aztreonam plus ceftazidime-avibactam as treatment of NDM-1-producing Klebsiella pneumoniae bacteraemia in a neutropenic patient: Last resort therapy? J Glob Antimicrob Resist. 2020;23:417–419. https://doi.org/10.1016/j.jgar.2020.10.019
27. Romero-Alvarez D, Reyes J, Quezada V, Satán C, Cevallos N, Barrera S, et al. First case of New Delhi metallo-β-lactamase in Klebsiella pneumoniae from Ecuador: An update for South America. Int J Infect Dis. 2017; 65:119–121. https://doi.org/10.1016/j.ijid.2017.10.012
28. Aguilar-Zapata D, Duran-Bedolla J, López-Jácome LE, Barrios-Camacho H, Garza-Ramos U, Valdez-Vázquez R. Klebsiella pneumoniae K2 producer of pyogenic liver abscess associated with biliary communication. J Infect Dev Ctries. 2022;16(9):1524–1529. https://doi.org/10.3855/jidc.15914
29. Cejas D, Elena A, Guevara Nuñez D, Sevilla Platero P, De Paulis A, Magariños F, et al. Changing epidemiology of KPC-producing Klebsiella pneumoniae in Argentina: Emergence of hypermucoviscous ST25 and high-risk clone ST307. J Glob Antimicrob Resist. 2019;18:238–242. https://doi.org/10.1016/j.jgar.2019.06.005
30. Sanctis G De, Ferraris A, Ducatenzeiler L, Benso J, Fernández-Otero L, Angriman F, et al. Factores predictores de mortalidad intrahospitalaria en pacientes adultos con infecciones por Klebsiella pneumoniae resistente a carbapenémicos y colistín: un estudio de cohorte retrospectivo. Rev Chilena Infectol. 2018; 35(3):239–245. https://doi.org/10.4067/s0716-10182018000300239
31. Rossi Gonçalves I, Ferreira ML, Araujo BF, Campos PA, Royer S, Batistão DWF, et al. Outbreaks of colistin-resistant and colistin-susceptible KPC-producing Klebsiella pneumoniae in a Brazilian intensive care unit. Journal of Hospital Infection. 2016;94(4):322–329. https://doi.org/10.1016/j.jhin.2016.08.019
32. Satán C, Satyanarayana S, Shringarpure K, Mendoza-Ticona A, Palanivel C, Jaramillo K, et al. Epidemiology of antimicrobial resistance in bacteria isolated from inpatient and outpatient samples, Ecuador, 2018. Rev Panam Salud Publica. 2023;47:14. https://doi.org/10.26633/RPSP.2023.14
33. Servicio Antimicrobianos E. Programa Nacional De Control De Calidad En Bacteriología Boletín Informativo Nro. 4-Abril 2021. 2021. http://antimicrobianos.com.ar/category/alerta/
34. Marquez C, Ingold A, Echeverría N, Acevedo A, Vignoli R, García-Fulgueiras V, et al. Emergence of KPC-producing Klebsiella pneumoniae in Uruguay: infection control and molecular characterization. New Microbes New Infect. 2014;2(3):58–63. https://doi.org/10.1002/nmi2.40
35. Organización Panamericana de la Salud. El impacto de la COVID-19 en la resistencia antimicrobiana. 2021. https://www.paho.org/es/noticias/17-11-2021-impacto-covid-19-resistencia-antimicrobiana
Published
Issue
Section
License
Copyright (c) 2023 Jennifer Dayana Erazo Bravo, Evelyn Katherine Jaramillo Ruales (Author)
This work is licensed under a Creative Commons Attribution 4.0 International License.
The article is distributed under the Creative Commons Attribution 4.0 License. Unless otherwise stated, associated published material is distributed under the same licence.
