Efficacy of Opuntia Ficus Extract as a lipid-lowering agent in experimental animals
DOI:
https://doi.org/10.56294/saludcyt2023672Keywords:
Normolipemiant, Opuntia ficus-indica, Cholesterol, HDL, LDL, TriglyceridesAbstract
Introduction: the therapeutic use of medicinal plants; It has been very useful to cure diseases since ancient times in application to "traditional medicine". There is an increase in "Chronic Noncommunicable Diseases", such as diabetes, atherosclerosis, hyperlipidemia, and stroke.
Aim: therefore, the lipid-lowering activity of Opuntia Ficus Indica was evaluated in Wistar rats.
Methods: seven groups of seven animals each were formed, normal group, negative (without treatment), positive (atorvastatin), group (Opuntia Streptacantha), 3 groups (opuntia ficus indica different doses). Initial values of the lipid profile were determined, hyperlipidemia was induced from the administration of a hypercaloric diet (31,52 % carbohydrates and 28,33 % total fat) for 60 days, once dyslipidemia was verified, the treatments were administered to each group, respectively. Determinations of lipid profile values were made at 7, 14 and 21 days of treatments.
Results: the results obtained: total cholesterol from the seventh day of administration of the post-hyperlipidemia treatments, regularized to normal values such as (58,1 ± 10 mg/dl), compared to the negative control (group B ) (127,25 ± 14,12 mg/dl), maintaining this trend on day 21 of treatment. The HDL from day 7 of administration the values began to normalize in all the OFI treatment groups (18,3 ± 3,4 mg/dl), on day 21 the group that was administered the dose of 62.5 mg/Kg, in which the HDL values (25,6±3,3 mg/dl) were normalized.
Conclusion: it is concluded that OFI extracts regulated lipid values in experimental animals
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