Effectiveness Test of Pumpkin Seed (Cucurbita moschata) Capsules and Multiple Micronutrient Supplement (MMS) on Nutrient Intake and Hemoglobin Levels in Pregnant Women with Chronic Energy Deficiency (CED)

Authors

  • Besse Nurul Fadillah Gaffar Hasanuddin University, Department of Nutrition Science, Makassar, Indonesia Author
  • Aminuddin Syam Hasanuddin University, Department of Nutrition Science, Makassar, Indonesia Author
  • Healthy Hidayanti Hasanuddin University, Department of Nutrition Science, Makassar, Indonesia Author https://orcid.org/0000-0003-4319-0011
  • Nurhaedar Jafar Hasanuddin University, Department of Nutrition Science, Makassar, Indonesia Author
  • Rahayu Indriasari Hasanuddin University, Department of Nutrition Science, Makassar, Indonesia Author

DOI:

https://doi.org/10.56294/saludcyt20262707

Keywords:

Pumpkin Seed (Cucurbita moschata), CED, Anemia, Pregnant Women, MMS

Abstract

Introduction: To compare the effects of pumpkin seed capsules and Multiple Micronutrient Supplements (MMS) on nutrient intake, Mid-Upper Arm Circumference (MUAC), and hemoglobin levels in pregnant women with CED and anemia. 
Methods: A quasi-experimental non-randomized pre–posttest control group design was conducted among 61 pregnant women. The intervention group received pumpkin seed capsules (2 × 700 mg/day), while the control group received MMS (30 mg iron + 15 micronutrients) for 60 days. 
Results: Both groups showed significant increases in nutrient intake, MUAC, and hemoglobin levels (p < 0,05). Mean MUAC increased by 1,83 cm in the intervention group and 1,55 cm in the control group. Hemoglobin levels rose by 1,48 g/dL and 1,47 g/dL, respectively, with no significant difference between groups (p > 0,05). 
Conclusion: Pumpkin seed capsules are as effective as MMS in improving nutritional status and hemoglobin levels among pregnant women with CED, suggesting their potential as a local food-based supplement.

References

1. RSST TP. Tim Promkes RSST. RSUP dr. Soeradji Tirtonegoro Klaten. 2022.

2. Akbarini OF, Siswina T. Factors Affecting the Incidence of Chronic Energy Deficiency (CED) in Pregnant Women. Sci Midwifery. 2022;10(5):3776–83. DOI: https://doi.org/10.35335/midwifery.v10i5.841

3. Kemenkes RI. Survey Kesehatan Indonesia (SKI). Vol. 01, Kemenkes BKPK. Kemenkes, BKPK; 2023. 1–965 p.

4. Rika Fitri Diningsih, Wiratmo PA, Erika Lubis. Hubungan Tingkat Pengetahuan Tentang Gizi Terhadap Kejadian Kekurangan Energi Kronik (Kek) Pada Ibu Hamil. Binawan Student J. 2021;3(3):8–15. DOI: https://doi.org/10.54771/bsj.v3i3.327

5. Reski RN. Anemia, Chronic Energy Deficiency and Their Relationship in Preconception Women. Enfermería Clínica. 2020;30(6):76–80. DOI: https://doi.org/10.1016/j.enfcli.2020.06.018

6. Reski RN. Food Intake and Anemia among Preconception Women in Takalar District, Indonesia. Enfermería Clínica. 2021;31(5):S834–9. DOI: https://doi.org/10.1016/j.enfcli.2021.10.009

7. Dinas Kesehatan Kabupaten Takalar. Profil Kesehatan Kabupaten Takalar. In Kabupaten Jeneponto; 2023.

8. Nurmasari V, Sumarmi S. Hubungan Keteraturan Kunjungan Antenatal Care dan Kepatuhan Konsumsi Tablet Fe dengan Kejadian Anemia pada Ibu Hamil Trimester III di Kecamatan Maron Probolinggo Relation between Regularity of Antenatal Care Visits and Compliance of Iron Tablets Consumpti. 2019;46–51. DOI: https://doi.org/10.20473/amnt.v3i1.2019.46-51

9. Kshatri JS, Satpathy P, Sharma S, Bhoi T, Mishra SP, Sahoo SS. Health research in the state of Odisha, India: A decadal bibliometric analysis (2011‑2020). J Fam Med Prim Care. 2022;6(2):169–70. DOI: https://doi.org/10.4103/jfmpc.jfmpc_2192_21

10. Sari, Helmita., Yarmaliza. Z. JURMAKEMAS (Jurnal Mahasiswa Kesehatan Masyarakat) Volume 2 Nomor 1, Februari 2022| 178. 2022;2:178–202. DOI: https://doi.org/10.14710/jkm.v10i2.32589

11. UNICEF Indonesia. Laporan Tahunan Indonesia 2022. UNICEF Lap Tah Indones 2022. 2022;6.

12. Wijianto W, Said R, Galenso N. Status Gizi Ibu Hamil dan Kepatuhan Minum Multifle Micronutrien Di 10 Desa Lokus Stunting Di Kabupaten Banggai. Poltekita J Ilmu Kesehat. 2022;16(1):98–102. DOI: https://doi.org/10.33860/jik.v16i1.716

13. Patterson KK, Gage WH, Brooks D, Black SE, McIlroy WE. Evaluation of gait symmetry after stroke: A comparison of current methods and recommendations for standardization. Gait Posture. 2010;31(2):241–6. DOI: https://doi.org/10.1016/j.gaitpost.2009.10.014

14. Hidayati MN, Perdani RRW, Karima N. Peran Zink terhadap Pertumbuhan Anak. Majority. 2019;8:168–71.

15. Moradi S, Alivand M, KhajeBishak Y, AsghariJafarabadi M, Alipour M, Chilibeck PD, et al. The effect of omega3 fatty acid supplementation on PPARγ and UCP2 expressions, resting energy expenditure, and appetite in athletes. BMC Sports Sci Med Rehabil. 2021;13(1):48. DOI: https://doi.org/10.1186/s13102-021-00266-4

16. Syakur R, Syam A, Hadju V, Palutturi S, Hadi AJ, Hafid R, et al. The Effect of Pumpkin Seed Biscuits on Nutritional and Zinc Status: A Randomized Controlled Trial in Pregnant Women. Open Access Maced J Med Sci. 2022;10(E):1161–8. DOI: https://doi.org/10.3889/oamjms.2022.9937

17. Nurrahmi AT. PENGARUH KAPSUL BIJI LABU KUNING (CUCURBITA MOSCHATA) TERHADAP LINGKAR LENGAN ATAS DAN KADAR HEMOGLOBIN IBU HAMIL KEKURANGAN ENERGI KRONIK. 2023;

18. Harlinah H, Haumahu CM. Efektivitas Ekstrak Biji Labu Kuning (Cucurbita) Terhadap Kadar Hemoglobin. Malahayati Nurs J. 2022;4(3):543–652. DOI: https://doi.org/10.33024/mnj.v4i3.6040

19. WHO. Nutrition of Women in the preconseption period, during pregnancy and the breastfeeding period report by the secretariat. World Health Organization. 2018;

20. Utami R, Gunawan IMA, Aritonang I. Pengaruh Pemberian Makanan Tambahan ( PMT ) Pemulihan terhadap Status Gizi pada Ibu Hamil di Kabupaten Sleman. 2018;20(1):19–26. DOI: https://doi.org/10.29238/jnutri.v20i1.115

21. Gupta, P.C., Bhattacharyya, S., Sharma, N., Kesharwani, R.K., & Keservani RK. Micronutrients and Macronutrients as Nutraceuticals (1st ed.). Apple Academic Press.; 2024. DOI: https://doi.org/10.1201/9781003415381

22. Musaidah M, Wahyu A, Abdullah AZ, Syafar M, Hadju V, Syam A. The Effect of Pumpkin Seeds Biscuits and Moringa Extract Supplementation on Hemoglobin , Ferritin , C-reactive protein , and Birth Outcome for Pregnant Women : A Systematic Review. 2021;9:360–5. DOI: https://doi.org/10.3889/oamjms.2021.6903

23. Mashayekh-Amiri S, Delavar MA, Bakouei F, Faramarzi M, Esmaeilzadeh S. The impact of myo-inositol supplementation on sleep quality in pregnant women: a randomized, double-blind, placebo-controlled study. J Matern Neonatal Med. 2022 Sep;35(18):3415–23. DOI: https://doi.org/10.1080/14767058.2020.1818225

24. Gouda M, Bekhit AE din, Tang Y, Huang Y, Huang L. Ultrasonics Sonochemistry Recent innovations of ultrasound green technology in herbal phytochemistry : A review. Ultrason Sonochem. 2021;73(December 2020):105538. DOI: https://doi.org/10.1016/j.ultsonch.2021.105538

25. Ahsan AK, Pediatrics F, Tebha SS, Sangi R, Pediatrics F, Kamran A, et al. Zinc Micronutrient Deficiency and Its Prevalence in Malnourished Pediatric Children as Compared to Well-Nourished Children : A Nutritional Emergency. 2021;22–3. DOI: https://doi.org/10.1177/2333794X211050316

26. Hall JE. Guyton and Hall Textbook of Medical Physiology. 12th ed. Philadelphia (PA): Elsevier; 2016.

27. Syahputra G, Agency I. Metabolisme Seng. 2024.

28. Haider BA, Olofin I, Wang M, Spiegelman D, Ezzati M, Fawzi WW. Anaemia, prenatal iron use, and risk of adverse pregnancy outcomes: systematic review and meta-analysis. BMJ. 2013 Jun;346:f3443. DOI: https://doi.org/10.1136/bmj.f3443

29. Bhutta ZA, Imdad A, Ramakrishnan U, Martorell R. Is it time to replace iron folate supplements in pregnancy with multiple micronutrients? Paediatr Perinat Epidemiol. 2012 Jul;26 Suppl 1:27–35. DOI: https://doi.org/10.1111/j.1365-3016.2012.01313.x

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Published

2026-01-01

How to Cite

1.
Fadillah Gaffar BN, Syam A, Hidayanti H, Jafar N, Indriasari R. Effectiveness Test of Pumpkin Seed (Cucurbita moschata) Capsules and Multiple Micronutrient Supplement (MMS) on Nutrient Intake and Hemoglobin Levels in Pregnant Women with Chronic Energy Deficiency (CED). Salud, Ciencia y Tecnología [Internet]. 2026 Jan. 1 [cited 2026 Feb. 25];6:2707. Available from: https://sct.ageditor.ar/index.php/sct/article/view/2707