Saccharum spontaneum: for protection against complications associated with high fat diet induced obesity and hyperlipidemia in experimental rodents
DOI:
https://doi.org/10.56294/saludcyt20262666Keywords:
Antihyperlipidemic, antiobesity, hydroalcoholic extract, Saccharum spontaneumAbstract
Introduction
Saccharum spontaneum Linn. (Family: Poaceae) known as Kasa or wild sugar cane. It is considered as a preciousremedial herb in traditional systems of medicine in India.The aim of this study was to determine the antiobesity and antihyperlipidemic activity of hydro-alcoholic root extractof Saccharum spontaneum (SPRE) in high fat diet (HFD) inducedobese rats.
Methods
The female Sprague-Dawley (SD) rats were divided into six groups (n = 6). SPRE at a dose of 100, 200, 400 mg/kg, p.o. and Sibutramine (5 mg/kg,p.o.) as reference drug was administered daily using animal feeding needles for 60 days. The experimental animals were allocated into normal control group (Group I) administered with regular lab. diet, control obese group (Group II) induced with HFD, reference drug sibutramineplus HFD group (Group III) and SPRE (100, 200 and 400 mg/kg) plus HFD group(Group IV, V and VI respectively). Its effect on body weight, organ fat pad, serum lipid profile (TC, HDL, TG, LDL, and VLDL), aspartate aminotransferase (AST), alanine aminotransferase (ALT), blood urea nitrogen(BUN) and creatinine level were estimated in HFD induced obese rats.
Results
The administration of SPRE (200 and 400 mg/kg) supplemented with HFD showed controlled body weight and organ fat pad increment, and reduced the TC, LDL, VLDL, TG,and increased the HDL levels as well as reduced the AST, ALT, and BUN significantly (P< 0,01). The creatinine levels showed less significant effects when compared with HFD treated group. While SPRE at 100 mg/kg did not display any significant (P> 0.01) effect on these parameters.
Conclusion
The results of the present study scientifically proven the traditional use of Saccharum spontaneumas an antiobesity and antihyperlipidemic agent as it normalized the raised body weight and organ fat pad weight as well as antihyperlipidemic property by lowering the changed levels of lipid profile in female SD rats.
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