Taxonomy and chemical composition of genus Apium
DOI:
https://doi.org/10.56294/saludcyt20262559Keywords:
Flavonoids, coumarins, Apium, leptophyllum, gravelones, antioxidant, volatile oilsAbstract
Family Apiaceae (Umbelliferae) is a unique family in the flowering plants due to its characteristic inflorescences and fruits besides the distinctive chemistry reflected in odor, flavor and even toxicity of many of its members. Plants of the family Apiaceae are usually used medicinally as a cure for gastrointestinal complaints, cardiovascular ailments, they are also used as antispasmodics, sedatives and a source of resins, gum resins, flavouring agents, flavonoids, coumarins , foods and even poisons. Subfamily Apioideae comprises numerous members reputed for their high content of coumarins, flavonoids and volatile oils. One member belonging to this subfamily were chosen as a subject for the present work, viz. Apium. Taxonomy, phytochemicals and biological activities of genus Apium were listed here.
References
[1] M. Hickey and C. King, 1998, Common Families of Flowering Plants, Cambridge Univeristy Press, 107.
[2] G. M Mahran, 1967, Medicinal Plants, 1st , Ed., Cairo University Press, Cairo, p. 353.
[3] C. L. Porter, 1069, Taxonomy of Flowering Plants, Eurasia Publishing House (PVT) LTD, Ram Nagar and New Delhi, p. 346.
[4] P. Shukla and S. P. Misra, 1997, An Introduction to Taxonomy of Angiosperms, Vikas Publishing House, 432.
[5] V. H Heywood,1985, Flowering Plants of the world, Equinox (Oxford) Ltd, Littlegate House, Oxford. England, 219-221.
[6] T. G Tutin, V. H. Heywood, N. A Burges, D. M Moore, D. H Valentine, S. M Walters, D. A Webb, 1981, Flora Europaea, Vol. 2, Cambridge University Press, London, New York, New Rochelle, Melbourne, Sydney, 315-375.
[7] L. Boulos, 1999, Flora of Egypt, Vol. Π, Al Hadara Publishing, Cairo, Egypt, 181-184.
[8] J. B Harborne, 1971, Flavonoid and phenyl propanoid patterns in the Umbelliferae, , in “The Biology and Chemistry of The Umbelliferae”, Heywood, V. H. (edit.), Academic Press, London and New York, 293.
[9] R. J. Park and M. D. Sutherland, 1969, Constituents of Apium leptophyllum in relation to tainting of milk, Aust. J. Chem., 22, 495-496. DOI: https://doi.org/10.1071/CH9690495
[10] S. Brasil, A. Gilbertoand, L. Bauer, 1971, Essential oils of Apium leptophyllum. Revista Brasileira de Farmacia, 52, 15-20 .
[11] E. M. Abd El-Aziz, 1992, GC/MS and antimicrobial activity of volatile oil of Apium leptophyllum (Benth.), Zag. J. Pharm. Sci., 1, 55-59 . DOI: https://doi.org/10.21608/zjps.1992.189020
[12] F. Shinichi and M. Kayo, 2002, Constituents of the Essential Oil of Apium leptophyllum, Koryo, Terupen oyobi Seiyu Kagaku ni Kansuru Toronkai Koen Yoshishu. 46, 19-21.
[13] J. E. Simon, A. F. Chadwick and L. E. Craker,1984, The Scientific Literature on selected herbs and aromatic and medicinal plants of the temperate zone, Archon Books, 770.
[14] A. J. Macleod, G. Macleod and G. Subramanian, 1988, Volatile aroma constituents of celery, Phytochemistry, 27, 373-375. DOI: https://doi.org/10.1016/0031-9422(88)83101-7
[15] G. Macleod and J. M. Ames, 1989, Volatile components of Celery and celeriac, Phytochemistry, 28, 1817-1824. DOI: https://doi.org/10.1016/S0031-9422(00)97866-X
[16] J. Tang, Y. Zhang, T. G. Hartman, R. T. Rosen, and C. Ho, 1990, Free and glycosidically bound volatile compounds in fresh Celery (Apium graveolens L.), J. Agric. Food Chem. 38, 1937-1940. DOI: https://doi.org/10.1021/jf00100a013
[17] A. F. Halim, M. M. Mashaly, O. M. Salama, A. F. Ali and P. Sandra, 1990, Analysis of celery fruit oil and investigation of the effect of storage, Egypt J. Pharm. Sci., 31, 107-113.
[18] D. Bartschat, T. Beck and A. Mosandi,1997, Stereoisomeric flavor compounds. 79. Simultaneous enantioselective analysis of 3-butylphthalide and 3-butylhexahydrophthalide stereoisomers in Celery, Celeriac and Fennel, J. Agric. Food Chem. 45, 4554-4557. DOI: https://doi.org/10.1021/jf970491f
[19] R. A. Momin, R. S. Ramsewak, and M. G Nair, 2000, Bioactive Compounds and 1,3-di[(cis)-9-octadecenoyl]-2-[(cis, cis)-9,12-octadecadienoyl] glycerol from Apium graveolens L. seeds, J. Agric. Food Chem., 48, 3785-3788. DOI: https://doi.org/10.1021/jf991383r
[20] R. A. Momin, and M. G Nair, 2001, Mosquitocidal, Nematicidal and Antifungal compounds from Apium graveolens L. seeds, J. Agric. Food Chem., 49, 142-145. DOI: https://doi.org/10.1021/jf001052a
[21] A. Sipailiene, P. R. Venskutonis, , A. Sarkinasand, V. Cypiene, 2005, Composition and antimicrobial activity of Celery (Apium graveolens) leaf and root extracts obtained with liquid carbon dioxide, Perspectives in Natural Product Chemistry, 3, 71-77. DOI: https://doi.org/10.17660/ActaHortic.2005.677.9
[22] H. B. Sowbhagya, P. Srinivas, and S. R. D Sampathu, 2006, Isolation of phthalides from celery seed oil, Counc. Sci. Industr. Res., Ind., 10.
[23] Ahmed I Foudah, Mohammed H Alqarni, Alam, Aftab; Salkini, Mohammad Ayman; Alam, Pravej; , Faisal K Alkholifi., Hasan S Yusufoglu,., 2021, Determination of Chemical Composition, In Vitro and In Silico Evaluation of Essential Oil from Leaves of DOI: https://doi.org/10.3390/molecules26237372
Apium graveolens Grown in Saudi Arabia, Molecules , 26(23), 7372.
[24] I. Umadevi and M. Daniel, 1990, Phenolics of some fruit spices of the Apiaceae, Nation. Acad. Sci. Lett., 13, 439-341.
[25] J. B Harborne and A. C Williams, 1972, Flavonoid patterns in the fruits of the Umbelliferae, Phytochemistry, 11, 1741-1750. DOI: https://doi.org/10.1016/0031-9422(72)85030-1
[26] F. Ko, T. Huang and C. Teng, 1991, Vasodilatory action mechanisms of apigenin isolated from Apium graveolens in rat thoracic aorta, Biochim. Biophys. Acta, 1115, 69-74. DOI: https://doi.org/10.1016/0304-4165(91)90013-7
[27] A. Crozier, M. E. J. Lean, M. S. Mcdonald and C. Black, 1997, Quantitative analysis of the flavonoid content of commercial Tomatoes, Onions, Lettuce and Celery.”, J. Agric. Food Chem., 45, 590-595. DOI: https://doi.org/10.1021/jf960339y
[28] K. H. Miean and S. Mohamed, 2001, Flavonoid (Myricetin, Quercetin, Kaempferol, Luteolin and Apigenin) content of edible tropical plants, J. Agric. Food Chem., 49, 3106-3112. DOI: https://doi.org/10.1021/jf000892m
[29] T. Mencherini, A. Cau, G. Bianco, R. D. Loggia, R. P. Aquino and G. Autore, 2007, An extract of Apium graveolens var. dulce leaves: structure of the major constituent, apiin, and its anti-inflammatory properties, J. Pharm. Pharmacol., 59, 891-897. DOI: https://doi.org/10.1211/jpp.59.6.0016
[30] L. Lin, S. Lu and J. M. Harnly, 2007, Detection and Quantification of Glycosylated Flavonoid Malonates in Celery, Chines Celery and Celery seed by LC-DAD-ESI/MS, J. Agric. Food Chem., 55, 1321-1326. DOI: https://doi.org/10.1021/jf0624796
[31] R. A. Momin and M. G. Nair, 2002, Antioxidant, cyclooxygenase and topoisomerase inhibitory compounds from Apium graveolens Linn. seeds, Phytomedicine 9, 312-318.
[32] F. Bohlmann, 1971, Acetylenic compounds in the Umbelliferae, in The Biology and Chemistry of The Umbelliferae, V. H. Heywood, (edit.), Academic Press, London and New York, 279.
[33] C. Zidorn, K. Johrer, M. Ganzera, B. Schubert, E. M. Sigmund, J. Mader, R. Greil, E. P. Ellmerer and H. Stuppner, 2005, Polyacetylenes from the Apiaceae vegetables carrot, celery, fennel, parsley and parsnip and their cytotoxic activities, J. Agric. Food Chem., 53, 2518-2523. DOI: https://doi.org/10.1021/jf048041s
[34] C. K. Atal, B. R. Sharma and J. S. Qadry, 1973, Coumarins from Trachyspermum roxburghianum and Apium leptophyllum, Ind. J. Pharm., 35, 127-128.
[35] P. Sharma, M. Sharma and S. Rangaswami, 1978, Structure of leptophyllidin, leptophyllin and leptophylloside, new dihydrofuranocoumarins from the seeds of Apium leptophyllum. Ind. J. Chem., 16B, 563-566. DOI: https://doi.org/10.1002/chin.197852211
[36] B.R Sharma and P.Sharma, 1979, Structure of leptophyllidin and identity of leptophyllin and leptophylloside with rutaretin and isorutarin.”, Ind. J. Chem., 17 B, 647-648.
[37] B.R. Sharma, R. K. Rattan and S. Perveen, 1980, Anhydrorutaretin, a new furanocoumarin, and other minor constituents of Apium leptophyllum seeds, Phytochemistry, 19, 1556-1557. DOI: https://doi.org/10.1016/0031-9422(80)80223-8
[38] R. C. Beier, G. W. Ivie, E. H. Oertli and D. L Holt, 1983, HPLC analysis of linear furanocoumarins (psoralens) in healthy celery (Apium graveolens); Food Chem. Toxic., 21 163-165. DOI: https://doi.org/10.1016/0278-6915(83)90231-4
[39] T. Vo-Dinh, D. A White, M. A. O`Malley, P. J. Seligman and R. C Beier, 1988, Fluorescence detection of phototoxic psoralens in vegetable products., J. Agric. Food Chem., 36, 333-337 . DOI: https://doi.org/10.1021/jf00080a022
[40] H. N. Nigg, J. O. Strandberg, R. C. Beier, H. D. Petersen and J. M. Harrison, 1997, Furanocoumarins in Florida Celery varieties increased by fungicide treatment., J. Agric. Food Chem., 45, 1430-1436. DOI: https://doi.org/10.1021/jf960537p
[41] S.K. Garg, S. R. Gupta and N. D Sharma, 1979b, Coumarins from Apium graveolens seeds, Phytochemistry, 18, 1580-1581. DOI: https://doi.org/10.1016/S0031-9422(00)98508-X
[42] O. Ceska, S. K Chaudhary, P. J. Warrington, M. J. Ashwood-Smith, 1986, Photoactive furanocoumarins in fruits of some umbellifers”; Phytochemistry 26, 165-169. DOI: https://doi.org/10.1016/S0031-9422(00)81503-4
[43] M. M. Diawara, J. T. Trumble and C. F Quiros, 1993, Linear furanocoumarins of three celery breeding lines implications for integrated pest management., J. Agric. Food Chem., 41, 819-824. DOI: https://doi.org/10.1021/jf00029a027
[44] S.K. Garg, S. R. Gupta and N. D Sharma, 1979a, Minor phenolics of Apium graveolens seeds., Phytochemistry, 18, 352. DOI: https://doi.org/10.1016/0031-9422(79)80102-8
[45] S.K. Garg, S. R. Gupta, and N. D Sharma, 1979 c, Apiumoside, a new furanocoumarin glucoside from the seeds of Apium graveolens.”, Phytochemistry, 18, 1764-1765. DOI: https://doi.org/10.1016/0031-9422(79)80214-9
[46] S.K Garg, S. R. Gupta and N. D Sharma, 1978, Apiumetin, a new furanocoumarin from the seeds of Apium graveolens, Phytochemistry, 17, 2135-2136. DOI: https://doi.org/10.1016/S0031-9422(00)89300-0
[47] L. Qiao, H. Chen, S. Liang and L. Jin, 2006, GC-MS analysis of low polarity components from Apium graveolens seeds, Jiefangjun Yaoxue Xuebao, 22, 101-103.
[48] J. Lu, X. Mou, W. Wang, L. Liao and A. Haji, 2006, Studies Chemical constituents of seeds of Apium graveolens L., Shizhen Guoyi Guoyao, 17, 6-7.
[49] J. Kitajima, T. Ishikawa and M. Satoh, 2003, Polar constituents of celery seed., Phytochemistry, 64, 1003-1011. DOI: https://doi.org/10.1016/S0031-9422(03)00461-8
[50] J. Schmidt, B. Voigt and G. Adam, 1995, 2-Deoxybrassinolide- a naturally occurring brassinosteroide from Apium graveolens., Phytochemistry, 40, 1041-1043. DOI: https://doi.org/10.1016/0031-9422(95)00363-C
[51] U. Afek, S. Carmeli, and N. Aharoni, 1995, Columbianetin, a phytoalexin associated with celery resistance to pathogens during storage, Phytochemistry, 39, 1347-1350. DOI: https://doi.org/10.1016/0031-9422(95)00125-Q
[52] S. K. Banerjee and K. Singh, 1995, A novel acid from Apium leptophyllum, J. Ind. Council Chem., 11, 39-41.
[53] L. P. Christensen and K. Brandt, 2006, Bioactive polyacetylenes in food plants of the Apiaceae family: occurrence, bioactivity and analysis., J. Pharm. Biomed. Anal., 41, 683-693. DOI: https://doi.org/10.1016/j.jpba.2006.01.057
[54] D. P. Papachristos and D. C. Stamopoulos, 2002, Repellent, toxic and reproduction inhibitory effects of essential oil vapours on Acanthoscelides obtectus (Say)., J. Stored Prod. Res., 38, 117-128. DOI: https://doi.org/10.1016/S0022-474X(01)00007-8
[55] B. Tuetun, W. Choochote, D. Kanjanapothi, E. Rattanachanpichai, U. Chaithong, P. Chaiwong, A. Jitpakdi, P. Tippawangkosol, D. Riyong, and B. Pitasawat, 2005, Repellent properties of celery compared with commercial repellents against mosquitoes under laboratory and field conditions., Trop Med Int Health, 10, 1190-1198. DOI: https://doi.org/10.1111/j.1365-3156.2005.01500.x
[56] B. Pitasawat, D. Champakaew, W. Choochote, A. Jitpakdi, U. Chaithong, D. Kanjanapothi, E. Rattanachanpichai, P.Tippawangkosol, D. Riyong, B. Tuetun and D. Chaiyasit, 2007, Aromatic plant-derived essential oil: An alternative larvicide for mosquito control.”; Fitoterapia, 1-6. DOI: https://doi.org/10.1016/j.fitote.2007.01.003
[57] H. Madari and R. S Jacobs, 2004, An analysis of cytotoxic botanical formulations used in the traditional medicine of ancient Persia as abortifacients.”; J. Nat. Prod., 67, 1204-1210. DOI: https://doi.org/10.1021/np049953r
[58] M. K. Al-Hindawi, I. H. S. Al-Deen, M. H. A. Nabi and M. A Ismail, 1989, Anti-inflammatory activity of some Iraqi plants using intact rats., J. Ethnopharmacol., 26, 163-168. DOI: https://doi.org/10.1016/0378-8741(89)90063-9
[59] A. H. Atta and A. Alkofahi, 1998, Anti-nociceptive and anti-inflammatory effects of some Jordanian medicinal plant extracts., J. Ethnopharmacol., 60, 117-124. DOI: https://doi.org/10.1016/S0378-8741(97)00137-2
[60] R. A. Momin and M. G. Nair, 2002, Antioxidant, cyclooxygenase and topoisomerase inhibitory compounds from Apium graveolens Linn. Seeds, Phytomedicine 9, 312-318. DOI: https://doi.org/10.1078/0944-7113-00131
[61] M. Popovic, B. Kaurinovic, S. Trivic, N. Mimica-Dukic and M. Bursac, 2006, Effect of celery extracts on some biochemical parameters of oxidative stress in mice treated with carbon tetrachloride.”; Phytother. Res., 20, 531-537. DOI: https://doi.org/10.1002/ptr.1871
[62] D. Prakash, S. Suri, G. Upadhyay and B. N Singh, 2007, Total phenol, antioxidant and free radical scavenging activities of some medicinal plants., Internat. J. Food Sci. Nutr., 58, 18-28. DOI: https://doi.org/10.1080/09637480601093269
[63] Sahoo, Himanshu Bhusan; Bhattamisra, Subrat Kumar; Biswas, Uttam Kumar; Sagar, Rakesh, 2013, Estimation of total phenolics and flavonoidal contents as well as in vitro antioxidant potential of Apium leptophyllum Pers., Herba Polonica , 59(3), 37-50. DOI: https://doi.org/10.2478/hepo-2013-0015
[64] A. Singh and S. S. Handa, 1995, Hepatoprotective activity of Apium graveolens and Hygrophila auriculata against paracetamol and thioacetamide intoxication in rats., J. Ethnopharmacol., 49, 119-126. DOI: https://doi.org/10.1016/0378-8741(95)01291-5
[65] S. Sultana, S. Ahmed, T. Jahangir and S. Sharma, 2005, Inhibitory effect of celery seeds extract on chemically induced hepatocarcinogenesis: modulation of cell proliferation, metabolism and altered hepatic foci development., Cancer letters, 221, 11-20. DOI: https://doi.org/10.1016/j.canlet.2004.07.030
[66] Sohrabi, Farzaneh; Niazmand, Saeed; Mahmoudabady, Maryam; Niazmand, Mohammad Javad, 2021, The vasodilatory effect of Apium graveolens L (celery) seed in isolated rat aorta: The roles of endothelium,calcium and potassium channels, Avicenna Journal of Phytomedicine , 11(1), 44-53.
[67] He Yuan; Tian Yu-e; Chen Yan; Zhang Xiaoxia; Zhang Airong; Tian Li, 2020, Study on the lipid-modulating effects and antioxidant activity of the extract of Xinjiang Apium graveolens L.root in hyperlipidemia rats, Xinjiang Yike Daxue Xuebao, 43(4), 140-144.
[68] Dianat, Mahin; Veisi, Ali; Ahangarpour, Akram; Moghaddam, Hadi Fathi, 2015, The effect of hydro-alcoholic celery (Apium graveolens) leaf extract on cardiovascular parameters and lipid profile in animal model of hypertension induced by fructose, Avicenna Journal of Phytomedicine, 5(3), 203-209.
[69] K. Grube, V. Spiegler, A. Hensel, 2019, Antiadhesive phthalides from Apium graveolens fruits against uropathogenic E. coli, Journal of Ethnopharmacology , 237, 300-306. DOI: https://doi.org/10.1016/j.jep.2019.03.024
[70] Hardani, Ameneh; Afzalzadeh, Mohammad Reza; Amirzargar, Ashraf; Mansouri, Esrafil; Meamar, Zakieh, 2015, Effects of aqueous extract of celery (Apium graveolens L.) leaves on spermatogenesis in healthy male rats, Avicenna Journal of Phytomedicine , 5(2), 113-119.
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