Integrative Feature Learning from Mammographic Images Using a Hybridized Diagnostic Model
DOI:
https://doi.org/10.56294/saludcyt20252207Keywords:
Breast Cancer Classification, Mammogram images, Deep Learning, GTE, Improved Bilateral Filtering Technique, Grid Feature EncodingAbstract
Traditional Conventional machine learning approaches to breast cancer diagnosis tend to rely on manual feature extraction, which is fraught with variability and time-consuming. These constraints limit the scalability and consistency of diagnostic platforms. As the need for precise and efficient diagnostic technologies escalates, the need for automated frameworks that can effectively interpret mammographic data and facilitate clinical decision-making arises. This paper introduces the Feature-driven Breast Cancer Classification Model (F-BCC-ML), which is intended to optimize diagnostic precision and efficiency in the detection of breast cancer. The goal is to create a hybridized model that can automate feature extraction and classification from mammogram images and eliminate the dependency on manual techniques to improve clinical results. The F-BCC-ML model combines an Adaptive Classifier Engine (ACE) with a strong preprocessing and segmentation pipeline. First, preprocessing of mammogram images is done for noise reduction using the Improved Bilateral Filtering Technique (IBFT), which maintains important anatomical information. Segmentation is achieved through SegNet, a deep learning architecture optimized for semantic segmentation. Feature extraction merges texture descriptors Weber Local Descriptor-harmonized Local Gabor XOR Pattern (GTE) and Grid Feature Encoding (GFE) with color and deep features from region-segmented regions. The features are subsequently classified as normal or cancerous via the ACE architecture in combination with a Deep Vision Network (DVN). The F-BCC-ML model showcases strong clinical promise through the automation of the diagnostic process and feature representation improvement.
References
1. Siegel RL, Giaquinto AN, Jemal A. Cancer statistics, 2024. CA Cancer J Clin. 2024;74(1):12–49, doi: 10.3322/caac.21820
2. Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024;74(3):229–63, doi: 10.3322/caac.21834.
3. AULESTIA-VIERA PV, RODRIGUES-FERNANDES CI, BRANDÃO TB, ROCHA AC, VARGAS PA, LOPES MA, et al. Malignant tumors affecting the head and neck region in ancient times: Comprehensive study of the CRAB Database. Braz Oral Res. 2024;38:1–10, doi: 10.1590/1807-3107bor-2024.vol38.0014.
4. Ready K, Arun B. Clinical assessment of breast cancer risk based on family history. JNCCN J Natl Compr Cancer Netw. 2010;8(10):1148–55, doi: 10.6004/jnccn.2010.0084.
5. Zhu JW, Charkhchi P, Adekunte S, Akbari MR. What Is Known about Breast Cancer in Young Women? Cancers (Basel). 2023;15(6):1–53, doi: 10.3390/cancers15061917.
6. Sun P, Yu C, Yin L, Chen Y, Sun Z, Zhang TT, et al. Global, regional, and national burden of female cancers in women of child-bearing age, 1990–2021: analysis of data from the global burden of disease study 2021. eClinicalMedicine [Internet]. 2024;74(32):102713. Available from: https://doi.org/10.1016/j.eclinm.2024.102713, doi: 10.1016/j.eclinm.2024.102713.
7. Ramamoorthy T, Kulothungan V, Sathishkumar K, Tomy N, Mohan R, Balan S, et al. Burden of cervical cancer in India: estimates of years of life lost, years lived with disability and disability adjusted life years at national and subnational levels using the National Cancer Registry Programme data. Reprod Health [Internet]. 2024;21(1). Available from: https://doi.org/10.1186/s12978-024-01837-7
8. Kulothungan V, Ramamoorthy T, Sathishkumar K, Mohan R, Tomy N, Miller GJ, et al. Burden of female breast cancer in India: estimates of YLDs, YLLs, and DALYs at national and subnational levels based on the national cancer registry programme. Breast Cancer Res Treat [Internet]. 2024;205(2):323–32. Available from: https://doi.org/10.1007/s10549-024-07264-3
9. Reprint SI, Ijaz MF. mdpi.com/journal/cancers Special Issue Reprint Recent Advances in Deep Learning and Medical Imaging for Cancer Treatment Edited by Muhammad Fazal Ijaz and Marcin Woźniak.
10. Li Y, Zhang H, Merkher Y, Chen L, Liu N, Leonov S, et al. Recent advances in therapeutic strategies for triple-negative breast cancer. J Hematol Oncol [Internet]. 2022;15(1):1–30. Available from: https://doi.org/10.1186/s13045-022-01341-0
11. Tacke F, Horn P, Wai-Sun Wong V, Ratziu V, Bugianesi E, Francque S, et al. AIinBreastCancerImaging:AnUpdateandFutureTrends. J Hepatol [Internet]. 2024;81(3):492–542. Available from: https://doi.org/10.1016/j.jhep.2024.04.031
12. Kalakattawi R, Gowharji L, Marzogi A, Alghamdi T. Evaluating Diagnostic Technologies for Breast Lesions : A Focused Review of Breast-Specific Gamma Imaging , Magnetic Resonance Imaging , Mammography , and Ultrasound with Molecular Subtype Insights. 2025;18(March):483–97.
13. Xiong X, Zheng LW, Ding Y, Chen YF, Cai YW, Wang LP, et al. Breast cancer: pathogenesis and treatments. Signal Transduct Target Ther. 2025;10(1), doi: 10.1038/s41392-024-02108-4.
14. Zebari DA, Ibrahim DA, Zeebaree DQ, Haron H, Salih MS, Damaševičius R, et al. Systematic Review of Computing Approaches for Breast Cancer Detection Based Computer Aided Diagnosis Using Mammogram Images. Appl Artif Intell [Internet]. 2021;35(15):2157–203. Available from: https://doi.org/10.1080/08839514.2021.2001177
15. Chen Y, Shao X, Shi K, Rominger A, Caobelli F. AI in Breast Cancer Imaging: An Update and Future Trends. Semin Nucl Med [Internet]. 2025;55(3):358–70. Available from: https://doi.org/10.1053/j.semnuclmed.2025.01.008.
16. Nairuz T, Lee D, Lee JH. Breast Ultrasound Computer-Aided Diagnosis System Based on Mass Irregularity Features in Frequency Domain. Appl Sci. 2024;14(17), doi: 10.3390/app14178003.
17. T R M, V VK, V DK, Geman O, Margala M, Guduri M. The stratified K-folds cross-validation and class-balancing methods with high-performance ensemble classifiers for breast cancer classification. Healthc Anal [Internet]. 2023;4(July):100247. Available from: https://doi.org/10.1016/j.health.2023.100247
18. Yaqub M, Jinchao F, Aijaz N, Ahmed S, Mehmood A, Jiang H, et al. Intelligent breast cancer diagnosis with two-stage using mammogram images. Sci Rep [Internet]. 2024;14(1):1–17. Available from: https://doi.org/10.1038/s41598-024-65926-0
19. Belsare A. Histopathological Image Analysis Using Image Processing Techniques: An Overview. Signal Image Process An Int J. 2012;3(4):23–36, doi: 10.5121/sipij.2012.3403.
20. Shankara C, Hariprasad SA, Latha DU. Detection of Lung Cancer Using Convolution Neural Network. SN Comput Sci [Internet]. 2023;4(3). Available from: https://doi.org/10.1007/s42979-022-01630-y
21. Zhao Y, Zhang J, Hu D, Qu H, Tian Y, Cui X. Application of Deep Learning in Histopathology Images of Breast Cancer: A Review. Micromachines. 2022;13(12):1–30, doi: 10.3390/mi13122197.
22. Gudur R, Patil N, Thorat ST. Early Detection of Breast Cancer using Deep Learning in Mammograms. J Pioneer Med Sci. 2024;13(2):18–27, doi: 10.61091/jpms202413204.
23. Gurumoorthy R, Kamarasan M. Breast Cancer Classification from Histopathological Images using Future Search Optimization Algorithm and Deep Learning. Eng Technol Appl Sci Res. 2024;14(1):12831–6, doi: 10.48084/etasr.6675.
Downloads
Published
Issue
Section
License
Copyright (c) 2025 Latha D U , Bhavani K G, Chethan B K, Shruthi N, Dharini K R (Author)

This work is licensed under a Creative Commons Attribution 4.0 International License.
The article is distributed under the Creative Commons Attribution 4.0 License. Unless otherwise stated, associated published material is distributed under the same licence.