Understanding the mother's knowledge and attitudes regarding newborn screening in rural areas of Tamil Nadu, India
DOI:
https://doi.org/10.56294/saludcyt20251886Keywords:
Newborn screening, Maternal Knowledge, Attitudes, Rural Healthcare, Tamil Nadu, Preventive Health, Logistic RegressionAbstract
Introduction: Newborn screening (NBS) is an effective intervention for congenital disorders that can prevent morbidity and mortality if accessible. The study aims to evaluate the knowledge, acceptance, and attitude towards newborn screening in Tamil Nadu, India, among rural mothers, and identify its determinants. Methods: A community-based, cross-sectional study was conducted at government and private hospitals in Thiruvallur District, Tamil Nadu, from June to August 2024. Data from 280 mothers who had recently given birth were analyzed. Statistical tests such as the Mann-Whitney U test, Kruskal-Wallis test, and multivariate logistic regression were used to identify predictors of maternal knowledge and attitudes via SPSS 25.0. Results: Only 37.5% of mothers demonstrated high knowledge of NBS, while 56.4% showed a positive attitude. Findings indicated that higher education (OR = 2.92, 95% CI: 1.99–4.29, p < 0.001) and prior knowledge of NBS (OR = 3.25, 95% CI: 2.18–4.85, p < 0.001) are strong predictors of awareness. Urban residency and higher family income significantly influenced understanding and favorable perceptions of NBS. Having a consanguineous marriage decreased the likelihood of positive attitude towards NBS (OR = 0.51, p = 0.033), suggesting a cultural barrier. Conclusion: The findings indicate that socio-demographic factors are significantly associated with maternal knowledge and attitudes towards NBS. It is essential to strengthen community educational programs to raise awareness of the NBS process and improve participation.
References
1. Ding S, Han L. Newborn screening for genetic disorders: Current status and prospects for the future. Pediatr Investig. 2022 Oct 24;6(4):291–8.
2. Therrell BL, Lloyd-Puryear MA, Ohene-Frempong K, Ware RE, Padilla CD, Ambrose EE, et al. Empowering newborn screening programs in African countries through establishment of an international collaborative effort. J Community Genet. 2020 Jul;11(3):253–68.
3. Rahimzadeh V, Friedman JM, de Wert G, Knoppers BM. Exome/Genome-Wide Testing in Newborn Screening: A Proportionate Path Forward. Front Genet [Internet]. 2022 Jul 4 [cited 2025 Jan 22];13. Available from: https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2022.865400/full
4. Therrell BL, Padilla CD, Borrajo GJC, Khneisser I, Schielen PCJI, Knight-Madden J, et al. Current Status of Newborn Bloodspot Screening Worldwide 2024: A Comprehensive Review of Recent Activities (2020–2023). Int J Neonatal Screen. 2024 May 23;10(2):38.
5. Kadiroğlu T, Altay G, Akay G, Can Bayrak Ç. Identification of maternal attitudes and knowledge about newborn screenings: a Turkey sample. J Community Genet. 2023 Dec;14(6):555–64.
6. Franková V, Dohnalová A, Pešková K, Hermánková R, O’Driscoll R, Ješina P, et al. Factors Influencing Parental Awareness about Newborn Screening. Int J Neonatal Screen. 2019 Sep 18;5(3):35.
7. Rivero-Arias O, Png ME, White A, Yang M, Taylor-Phillips S, Hinton L, et al. Benefits and harms of antenatal and newborn screening programmes in health economic assessments: the VALENTIA systematic review and qualitative investigation. Health Technology Assessment. 2024 Jun 27;28(25):1–180.
8. Nyande FK, Ricks E, Williams M, Jardien-Baboo S. Socio-cultural barriers to the delivery and utilisation of child healthcare services in rural Ghana: a qualitative study. BMC Health Serv Res. 2022 Mar 3;22:289.
9. Debsarma D, Choudhary BK. Exploring the socio-ecological factors of healthcare-seeking behaviour among patients/people from Rural Unqualified Health Providers in the rural settings in West Bengal, India. SSM - Health Systems. 2025 Jun 1;4:100046.
10. Pourfarzam M, Zadhoush F. Newborn Screening for inherited metabolic disorders; news and views. J Res Med Sci. 2013 Sep;18(9):801–8.
11. Moody L, Choudhry K. Parental views on informed consent for expanded newborn screening. Health Expect. 2013 Sep;16(3):239–50.
12. Wanduru P, Hanson C, Kwesiga D, Kakooza-Mwesige A, Mölsted Alvesson H, Waiswa P. Parental participation in newborn care in the view of health care providers in Uganda: a qualitative study. Reproductive Health. 2024 Oct 29;21(1):155.
13. Rama R, Gopalakrishnan S, PM U. Assessment of knowledge regarding new-born care among mothers in Kancheepuram district, Tamil Nadu. International Journal of Community Medicine and Public Health. 2014 Dec 31;1:58–63.
14. Shobichah S, Astuti A. Analysis of Social Factors In Improving Access and Utilization of Healthcare Services In the Community. International Journal of Social Health. 2023 Nov 27;2:367–73.
15. Portela Dos Santos O, Melly P, Hilfiker R, Giacomino K, Perruchoud E, Verloo H, et al. Effectiveness of Educational Interventions to Increase Skills in Evidence-Based Practice among Nurses: The EDITcare Systematic Review. Healthcare (Basel). 2022 Nov 2;10(11):2204.
16. Timotheou S, Miliou O, Dimitriadis Y, Sobrino SV, Giannoutsou N, Cachia R, et al. Impacts of digital technologies on education and factors influencing schools’ digital capacity and transformation: A literature review. Educ Inf Technol. 2023 Jun 1;28(6):6695–726.
17. Matsumura M, Gubhaju B. Women’s status, household structure and the utilization of maternal health services in Nepal. Asia-Pacific Population Journal. 2001 Mar 1;16:23–44.
18. Lawal T, Yusuf B, Fatiregun A. Knowledge of birth defects among nursing mothers in a developing country. African Health Sciences. 2015 Mar 12;15:180.
19. de Dios-Aguado M, Agulló-Ortuño MT, Ugarte-Gurrutxaga MI, Yañez-Araque B, Molina-Gallego B, Gómez-Cantarino S. Nutritional Health Education in Pregnant Women in a Rural Health Centre: Results in Spanish and Foreign Women. Healthcare (Basel). 2021 Sep 29;9(10):1293.
20. Kifle D, Azale T, Gelaw YA, Melsew YA. Maternal health care service seeking behaviors and associated factors among women in rural Haramaya District, Eastern Ethiopia: a triangulated community-based cross-sectional study. Reprod Health. 2017 Jan 13;14:6.
21. Hezekiah A I, Oparaugo CI, Ajetomobi GD, Fasina AE, Chianumba RI, Nnodu OE. Awareness, attitude, and acceptance of newborn screening for sickle cell disease among health workers and caregivers at primary healthcare centers in Gwagwalada Area Council, Federal Capital Territory, Abuja, Nigeria. Front Public Health [Internet]. 2025 Jan 7 [cited 2025 Mar 18];12. Available from: https://www.frontiersin.orgundefined/journals/public-health/articles/10.3389/fpubh.2024.1453727/full
22. Watson MS, Lloyd-Puryear MA, Howell RR. The Progress and Future of US Newborn Screening. Int J Neonatal Screen. 2022 Jul 18;8(3):41.
23. van Pelt S, Massar K, van der Eem L, Shields-Zeeman L, de Wit JBF, Ruiter RAC. “If you don’t have enough equipment, you’re not going to provide quality services”: Healthcare workers’ perceptions on improving the quality of antenatal care in rural Tanzania. International Journal of Africa Nursing Sciences. 2020 Jan 1;13:100232.
24. Johnson GS, Gundmi A. Knowledge and Attitude of Parents Residing in Urban and Rural Areas Towards Infant Hearing Loss. Indian J Otolaryngol Head Neck Surg. 2022 Dec;74(Suppl 3):6513–8.
25. Kruk ME, Gage AD, Arsenault C, Jordan K, Leslie HH, Roder-DeWan S, et al. High-quality health systems in the Sustainable Development Goals era: time for a revolution. Lancet Glob Health. 2018;6:e1196–252.
26. Aubrey-Basler K, Bursey K, Pike A, Penney C, Furlong B, Howells M, et al. Interventions to improve primary healthcare in rural settings: A scoping review. PLoS One. 2024 Jul 11;19(7):e0305516.
27. Maternal Attitudes and Knowledge About Newborn Screening. | Request PDF [Internet]. [cited 2025 Mar 18]. Available from: https://www.researchgate.net/publication/242015364_Maternal_Attitudes_and_Knowledge_About_Newborn_Screening
28. Botkin JR, Rothwell E, Anderson RA, Rose NC, Dolan SM, Kuppermann M, et al. Prenatal Education of Parents About Newborn Screening and Residual Dried Blood Spots. JAMA Pediatr. 2016 Jun 1;170(6):543–9.
29. Evans A, LeBlanc K, Bonhomme N, Shone S, Gaviglio A, Freedenberg D, et al. A Newborn Screening Education Best Practices Framework: Development and Adoption. International Journal of Neonatal Screening. 2019 Jun 1;5:22.
30. White MT. Making Sense of Genetic Uncertainty: The Role of Religion and Spirituality. Am J Med Genet C Semin Med Genet. 2009 Feb 15;151C(1):68–76.
31. Ghasemi A, Zahediasl S. Normality tests for statistical analysis: a guide for non-statisticians. Int J Endocrinol Metab. 2012 Spring;10(2):486-9. doi: 10.5812/ijem.3505. Epub 2012 Apr 20. PMID: 23843808; PMCID: PMC3693611.
32. McKnight, P.E. and Najab, J. (2010). Mann-Whitney U Test. In The Corsini Encyclopedia of Psychology (eds I.B. Weiner and W.E. Craighead). https://doi.org/10.1002/9780470479216.corpsy0524
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