Hematological alterations in major burn patients: a bibliographic review
DOI:
https://doi.org/10.56294/saludcyt20251646Keywords:
Burns, Hematologic disease, Blood Coagulation DisordersAbstract
Introduction: Burns and their treatment have been studied constantly. Even with all the accumulated knowledge about this topic there are still subjects related to the pathophysiology that need further research. Methods: A bibliographical review to characterize the hematological alterations documented in major burn patients was conducted. The source of information for this matter was mainly internet (Google Schoolar, Scopus, PubMed, Dialnet and others). Results: 16 texts in English and Spanish were read and referred on the paper. There were only contemplated articles, chapters of books, thesis and similar that were published within the last 5 years. Conclusions: The most common hematological alterations documented on medical literature are either the pro coagulating initial status or the rapid thrombocytopenia due to the dilutional coagulopathy. The sudden rupture of balance between the pro-coagulating and anti-coagulating factor could lead to serious complications such as disseminated intravascular coagulation. Other disturbances mentioned are acute anemia, monocyte anisocytosis, delay of PT-PTT and VTE. Although further investigation is needed for a better understanding of this topic, an individualized and multidisciplinary approach will always be the best course of action.
References
1. McCann C, Watson A, Barnes D. Major burns: Part 1. Epidemiology, pathophysiology and initial management. BJA Education. 1 de marzo de 2022;22(3):94-103; Disponible en: https://www.sciencedirect.com/science/article/pii/S2058534921001293
2. Pérez Casañas P. Afectación de la calidad de vida del paciente gran quemado. Una revisión bibliográfica. 2025 [citado 27 de febrero de 2025]; Disponible en: https://riull.ull.es/xmlui/handle/915/41335
3. Moya-Rosa EJ, Moya-Corrales Y, Moya-Rosa EJ, Moya-Corrales Y. Complicaciones en los pacientes quemados. Revista Archivo Médico de Camagüey [Internet]. 2022 [citado 27 de febrero de 2025];26. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_abstract&pid=S1025-02552022000100088&lng=es&nrm=iso&tlng=en
4. Rodríguez Llamazares T. Complicaciones en los grandes quemados. 2021 [citado 27 de febrero de 2025]; Disponible en: https://uvadoc.uva.es/handle/10324/47902
5. Korkmaz HI, Flokstra G, Waasdorp M, Pijpe A, Papendorp SG, de Jong E, et al. The Complexity of the Post-Burn Immune Response: An Overview of the Associated Local and Systemic Complications. Cells. enero de 2023;12(3):345; Disponible en: https://www.mdpi.com/2073-4409/12/3/345
6. Moins-Teisserenc H, Cordeiro DJ, Audigier V, Ressaire Q, Benyamina M, Lambert J, et al. Severe Altered Immune Status After Burn Injury Is Associated With Bacterial Infection and Septic Shock. Front Immunol [Internet]. 2 de marzo de 2021 [citado 27 de febrero de 2025];12. Disponible en: https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.586195/full
7. Żwierełło W, Piorun K, Skórka-Majewicz M, Maruszewska A, Antoniewski J, Gutowska I. Burns: Classification, Pathophysiology, and Treatment: A Review. International Journal of Molecular Sciences. enero de 2023;24(4):3749; Disponible en: https://www.mdpi.com/1422-0067/24/4/3749
8. Santaolalla Fragoso MB, Martín García AI, San Juan E. Grandes Quemados. Revista electrónica AnestesiaR. 2024;16(7):1; Disponible en: https://dialnet.unirioja.es/servlet/articulo?codigo=9676969
9. Britton GW, Wiggins AR, Halgas BJ, Cancio LC, Chung KK. Critical Care of the Burn Patient. Surgical Clinics. 1 de junio de 2023;103(3):415-26; Disponible en: https://www.surgical.theclinics.com/article/S0039-6109(23)00005-1/abstract
10. Guilabert P, Martin N, Usúa G, Vendrell M, Colomina MJ, Barret JP. Coagulation Alterations in Major Burn Patients: A Narrative Review. Journal of Burn Care & Research. 1 de marzo de 2023;44(2):280-92; Disponible en: https://doi.org/10.1093/jbcr/irac177
11. Barbier JM, Viana MV, Pantet O, Alberio L, Berger MM. Blood coagulation alterations over the first 10 days after severe burn injury. Burns Open. 1 de enero de 2022;6(1):10-8; Disponible en: https://www.sciencedirect.com/science/article/pii/S246891222100105X
12. Sankar V, Villa A. Hematologic Diseases. En: Burket’s Oral Medicine [Internet]. John Wiley & Sons, Ltd; 2021 [citado 27 de febrero de 2025]. p. 627-64. Disponible en: https://onlinelibrary.wiley.com/doi/abs/10.1002/9781119597797.ch17
13. Bordeanu-Diaconescu EM, Grosu-Bularda A, Frunza A, Grama S, Andrei MC, Neagu TP, et al. Venous Thromboembolism in Burn Patients: A 5-Year Retrospective Study. Medicina. febrero de 2024;60(2):258; Disponible en: https://www.mdpi.com/1648-9144/60/2/258
14. Bordeanu-Diaconescu EM, Grosu-Bularda A, Frunza A, Grama S, Andrei MC, Neagu TP, et al. Diagnostic and Prognostic Value of Thrombocytopenia in Severe Burn Injuries. Diagnostics. enero de 2024;14(6):582; Disponible en: https://www.mdpi.com/2075-4418/14/6/582
15. Du Y, Xia Y, You C, Wang Y, Duan D, Xu W, et al. Impact of red blood cell transfusion in massive burn: a multicenter cohort study. Sci Rep. 20 de febrero de 2025;15(1):6196; Disponible en: https://www.nature.com/articles/s41598-025-91052-6
16. Nazemidashtarjandi S, Muldur S, Supple MD, Ryan CM, Yonker LM, Karabacak MN, et al. Monocyte Anisocytosis Changes in Patients After Major Burn Injuries. Journal of Burn Care & Research. 1 de enero de 2025;46(1):138-44; Disponible en: https://doi.org/10.1093/jbcr/irae088.
Downloads
Published
Issue
Section
License
Copyright (c) 2025 Liliana Teruel Leyva , Ariana Karolina Guevara Álvarez , Juan Sebastián Loza Chiriboga , Luis Ramón Ramírez Verdezoto , Roy Alejandro Guevara Álvarez (Author)
This work is licensed under a Creative Commons Attribution 4.0 International License.
The article is distributed under the Creative Commons Attribution 4.0 License. Unless otherwise stated, associated published material is distributed under the same licence.
