Mucinous cystoadenoma of cecal appendix, pre-surgical diagnosis and treatment: case report
DOI:
https://doi.org/10.56294/saludcyt20251482Keywords:
Appendix, Appendiceal Neoplasms, Mucocele, ColectomyAbstract
Introduction: mucinous tumors of the appendix are a condition characterized by obstructive dilation of the cecal appendix caused by the intraluminal accumulation of mucous material. Their incidence is relatively low, accounting for approximately 0.2-0.3% of all appendectomies performed. Mucinous lesions are divided into two groups: 1. Non-neoplastic lesions (mucocele) 2. Neoplastic lesions (serrated polyps, hyperplastic polyps, low-grade mucinous appendiceal neoplasia, high-grade mucinous appendiceal neoplasia, mucinous adenocarcinoma). There is no typical clinical presentation for this pathology; however, it often presents as acute appendicitis or as a mass in the right lower quadrant. Improper management could lead to pseudomyxoma peritonei, which has a high mortality rate.
Clinic case: a case of a patient diagnosed preoperatively with a large appendiceal mucocele is presented. An exploratory laparotomy, right hemicolectomy, and ileotransverse anastomosis were performed with a good postoperative recovery. The histopathological result reported a mucinous cystadenoma of the appendix.
Conclusion: mucinous cystadenoma is an extremely rare pathology, and its perioperative identification is challenging due to its nonspecific clinical presentation. For this reason, tomography is recommended in the study of neoplasms of the right iliac fossa.
References
1. Lizárraga-Castro JA, Mejía-Picasso CA, García-Garrido E, et al. Tumor mucinoso del apéndice. Cir Gen. 2023;45(4):234-238. doi:10.35366/115850.
2. Shiihara M, Ohki T, Yamamoto M. Preoperative Diagnosis and Surgical Approach of Appendiceal Mucinous Cystadenoma: Usefulness of Volcano Sign. Case Rep Gastroenterol. 2017 Sep 15;11(3):539-544. doi: 10.1159/000480374. PMID: 29033775; PMCID: PMC5637000.
3. Cubro H, Cengic V, Burina N, Kravic Z, Beciragic E, Vranic S. Mucocele of the appendix presenting as an exacerbated chronic tubo-ovarian abscess: A case report and comprehensive review of the literature. Medicine (Baltimore). 2019 Sep;98(39):e17149. doi: 10.1097/MD.0000000000017149. PMID: 31574819; PMCID: PMC6775329.
4. Demetrashvili Z, Chkhaidze M, Khutsishvili K, Topchishvili G, Javakhishvili T, Pipia I, Qerqadze V. Mucocele of the appendix: case report and review of literature. Int Surg. 2012 Jul-Sep;97(3):266-9. doi: 10.9738/CC139.1. PMID: 23113858; PMCID: PMC3723229.
5. Rymer B, Forsythe RO, Husada G. Mucocoele and mucinous tumours of the appendix: A review of the literature. Int J Surg. 2015 Jun;18:132-5. doi: 10.1016/j.ijsu.2015.04.052. Epub 2015 Apr 24. PMID: 25917270.
6. Park K-J, Choi H-J, Kim S-H. Laparoscopic approach to mucocele of appendiceal mucinous cystadenoma: feasibility and short-term outcomes in 24 consecutive cases. Surg Endosc. 2015;29(11):3179–83.
7. Xu ZS, Xu W, Ying JQ, Cheng H. Mechanical intestinal obstruction secondary to appendiceal mucinous cystadenoma: A case report and brief review. Medicine (Baltimore). 2017 Feb;96(5):e6016. doi: 10.1097/MD.0000000000006016. PMID: 28151903; PMCID: PMC5293466.
8. Van Hooser A, Williams TR, Myers DT. Mucinous appendiceal neoplasms: pathologic classification, clinical implications, imaging spectrum and mimics. Abdom Radiol (NY). 2018 Nov;43(11):2913-2922. doi: 10.1007/s00261-018-1561-9. PMID: 29564494.
9. Koç C, Akbulut S, Akatlı AN, Türkmen Şamdancı E, Tuncer A, Yılmaz S. Nomenclature of appendiceal mucinous lesions according to the 2019 WHO Classification of Tumors of the Digestive System. Turk J Gastroenterol. 2020 Sep;31(9):649-657. doi: 10.5152/tjg.2020.20537. PMID: 33090102; PMCID: PMC7577417.
10. Foula MS, Alardhi AM, Othman SA, Mirza Gari MK. Laparoscopic management of appendicular mucinous cystadenoma, case report. Int J Surg Case Rep. 2019;54:87-89. doi: 10.1016/j.ijscr.2018.11.068. Epub 2018 Dec 12. PMID: 30562694; PMCID: PMC6297190.
11. Matias-García B, Mendoza-Moreno F, Blasco-Martínez A, Busteros-Moraza JI, Diez-Alonso M, Garcia-Moreno Nisa F. A retrospective analysis and literature review of neoplastic appendiceal mucinous lesions. BMC Surg. 2021 Feb 11;21(1):79. doi: 10.1186/s12893-021-01091-9. PMID: 33573654; PMCID: PMC7877070.
12. Hegg KS, Mack LA, Bouchard-Fortier A, Temple WJ, Gui X. Macroscopic and microscopic characteristics of low grade appendiceal mucinous neoplasms (LAMN) on appendectomy specimens and correlations with pseudomyxoma peritonei development risk. Ann Diagn Pathol. 2020 Oct;48:151606. doi: 10.1016/j.anndiagpath.2020.151606. Epub 2020 Aug 21. PMID: 32889392.
13. Merino C, Narváez D, Naveda D, Abdo E (2020) Low-Grade Appendiceal Mucinous Neoplasm and Acute Appendicitis. Clinical Case Report. Ar Med Surg Pathol 3: 104. DOI: 10.29011/AMSP-104.100004.
14. Zih FS, Wong-Chong N, Hummel C, Petronis J, Panzarella T, Pollett A, McCart JA, Swallow CJ. Mucinous tumor of the appendix with limited peritoneal spread: is there a role for expectant observation? Ann Surg Oncol. 2014 Jan;21(1):225-31. doi: 10.1245/s10434-013-3283-0. Epub 2013 Oct 8. Erratum in: Ann Surg Oncol. 2014 Dec;21 Suppl 4:S777. McCart, Andrea J [corrected to McCart, J Andrea]. PMID: 24100959.
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Copyright (c) 2025 Juan Cadena Baquero, Diana Naveda, Jeannie Canelos Largaespada, María Paula Villagomez, Patricio Galvez Salazar (Author)

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