Clinical Features of Oxygenation, Micro-Arousals, and Periodic Limb Movements in Sleep Bruxism: A Retrospective Study
DOI:
https://doi.org/10.56294/saludcyt20251465Keywords:
Sleep Bruxism, Cell Respiration, Sleep Arousal Disorders, Nocturnal Myoclonus SyndromeAbstract
This retrospective study compared oxygenation, hypopnea episodes, micro-arousals, and periodic limb movements in individuals with sleep bruxism and a control group. A total of 129 polysomnography records from 2011 to 2019 were analyzed (54 with SB, 74 controls). Subjects with sleep bruxism were classified according to Lavigne et al. (≥25 events/hour). Variables included sex, age, micro-arousals, oxygenation, hypopnea episodes, and periodic limb movements. The Mann-Whitney U test was used for comparisons. Subjects with sleep bruxism had a higher average number of micro-arousals: NMOR (SB: 29.5 vs. Control: 24.3) and MOR (sleep bruxism: 18.5 vs. Control: 13.2). Respiratory events with arousals were twice as frequent (sleep bruxism: 3.07 vs. Control: 1.69), and hypopnea episodes were more frequent and lasted longer in sleep bruxism (34.09 episodes, 11.5 sec) compared to controls (24.38 episodes, 7.4 sec). Oxygenation was lower in controls but remained within normal limits: NMOR (SB: 92.6 vs. Control: 89) and MOR (sleep bruxism: 92.9 vs. Control: 88). periodic limb movements frequency was also higher in sleep bruxism (sleep bruxism: 72.4 vs. Control: 65.7), though differences were not statistically significant (p > 0.05). In conclusion, sleep bruxism was associated with more frequent micro-arousals, hypopnea episodes, and periodic limb movements compared to controls, while oxygenation levels were lower in the control group.
References
1. Lobbezoo F, Ahlberg J, Glaros AG, Kato T, Koyano K, Lavigne GJ, et al. Bruxism defined and graded: An international consensus. J Oral Rehabil. 2013;40(1):2–4. DOI: 10.1111/joor.12011 DOI: https://doi.org/10.1111/joor.12011
2. Fan X, Qu F, Wang JJ, Du X, Liu WC. Decreased γ-aminobutyric acid levels in the brainstem in patients with possible sleep bruxism: A pilot study. J Oral Rehabil. 2017;44(12):934–40. DOI: 10.1111/joor.12572 DOI: https://doi.org/10.1111/joor.12572
3. Lavigne GJ, Rompré PH, Montplaisir JY. Sleep bruxism: validity of clinical research diagnostic criteria in a controlled polysomnographic study. J Dent Res. 1996;75(1):546–52. DOI: 10.1177/00220345960750010601 DOI: https://doi.org/10.1177/00220345960750010601
4. Carra MC, Huynh N, Lavigne G. Sleep bruxism: a comprehensive overview for the dental clinician interested in sleep medicine. Dent Clin North Am. 2012;56(2):387–413. DOI: 10.1016/j.cden.2012.01.003 DOI: https://doi.org/10.1016/j.cden.2012.01.003
5. van der Zaag J, Naeije M, Wicks DJ, Hamburger HL, Lobbezoo F. Time-linked concurrence of sleep bruxism, periodic limb movements, and EEG arousals in sleep bruxers and healthy controls. Clin Oral Investig. 2014;18(2):507–13.DOI: 10.1007/s00784-013-0994-3 DOI: https://doi.org/10.1007/s00784-013-0994-3
6. Beddis H, Pemberton M, Davies S. Sleep bruxism: An overview for clinicians. Br Dent J. 2018;225(6):497–501. DOI: 10.1038/sj.bdj.2018.757 DOI: https://doi.org/10.1038/sj.bdj.2018.757
7. Huynh N, Kato T, Rompré PH, Okura K, Saber M, Lanfranchi PA, et al. Sleep bruxism is associated to micro-arousals and an increase in cardiac sympathetic activity. J Sleep Res. 2006;15(3):339–46. DOI: 10.1111/j.1365-2869.2006.00536.x DOI: https://doi.org/10.1111/j.1365-2869.2006.00536.x
8. Kato T, Rompré P, Montplaisir JY, Sessle BJ, Lavigne GJ. Sleep bruxism: An oromotor activity secondary to micro-arousal. J Dent Res. 2001;80(10):1940–1944. DOI: 10.1177/00220345010800101501 DOI: https://doi.org/10.1177/00220345010800101501
9. Nashed A, Lanfranchi P, Rompré P, Carra MC, Mayer P, Colombo R, et al. Sleep bruxism is associated with a rise in arterial blood pressure. Sleep. 2012;35(4):529–536. DOI: 10.5665/sleep.1740 DOI: https://doi.org/10.5665/sleep.1740
10. Khoury S, Rouleau GA, Rompré PH, Mayer P, Montplaisir JY, Lavigne GJ. A significant increase in breathing amplitude precedes sleep bruxism. Chest. 2008;134(2):332–337. DOI: 10.1378/chest.08-0115 DOI: https://doi.org/10.1378/chest.08-0115
11. Lobbezoo F, Lavigne GJ. Do bruxism and temporomandibular disorders have a cause-and-effect relationship? J Orofac Pain. 1997;11(1):15–23. URL: https://pubmed.ncbi.nlm.nih.gov/10332307/
12. Hornyak M, Feige B, Riemann D, Voderholzer U. Periodic leg movements in sleep and periodic limb movement disorder: prevalence, clinical significance and treatment. Sleep Med Rev. 2006;10(3):169–77. DOI: 10.1016/j.smrv.2005.12.003 DOI: https://doi.org/10.1016/j.smrv.2005.12.003
13. Fulda S. Periodic Leg Movements During Sleep. Sleep Med Clin. 2021;16(2):289-303. DOI: 10.1016/j.jsmc.2021.02.004 DOI: https://doi.org/10.1016/j.jsmc.2021.02.004
14. Lavigne GJ, Huynh N, Kato T, Okura K, Adachi K, Yao D, Sessle B. Genesis of sleep bruxism: motor and autonomic-cardiac interactions. Arch Oral Biol. 2007;52(4):381-4. DOI: 10.1016/j.archoralbio.2006.11.017. DOI: https://doi.org/10.1016/j.archoralbio.2006.11.017
15. Martynowicz H, Gac P, Brzecka A, Poreba R, Wojakowska A, Mazur G, Smardz J, Wieckiewicz M. The Relationship between Sleep Bruxism and Obstructive Sleep Apnea Based on Polysomnographic Findings. J Clin Med. 2019;8(10):1653. DOI: 10.3390/jcm8101653. DOI: https://doi.org/10.3390/jcm8101653
16. Cuschieri S. The STROBE guidelines. Saudi J Anaesth. 2019 Apr;13(Suppl 1):S31-S34. DOI: 10.4103/sja.SJA_543_18. DOI: https://doi.org/10.4103/sja.SJA_543_18
17. World Medical Association. World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. JAMA. 2013;310(20):2191-4. DOI: 10.1001/jama.2013.281053. DOI: https://doi.org/10.1001/jama.2013.281053
18. Lavigne GJ, Khoury S, Abe S, Yamaguchi T, Raphael K. Bruxism physiology and pathology: an overview for clinicians. J Oral Rehabil. 2008;35(7):476-94. DOI: 10.1111/j.1365-2842.2008.01881.x DOI: https://doi.org/10.1111/j.1365-2842.2008.01881.x
19. López Soto OP, Castellanos Ruíz J, López Soto LM, López Echeverry YP, Quintero Marín YT, Cardona Londoño JW, et al. Evaluación interdisciplinaria del sistema estomatognático y de la postura en un sujeto diagnosticado con bruxismo del sueño: reporte de caso. Salud UIS. 2020; 52(2): 153-159. DOI: 10.18273/revsal.v52n2-2020009 DOI: https://doi.org/10.18273/revsal.v52n2-2020008
20. Serdar CC, Cihan M, Yücel D, Serdar MA. Sample size, power and effect size revisited: simplified and practical approaches in pre-clinical, clinical and laboratory studies. Biochem Med (Zagreb). 2021;31(1):010502. DOI: 10.11613/BM.2021.010502. DOI: https://doi.org/10.11613/BM.2021.010502
21. Shieh G. Effect size, statistical power, and sample size for assessing interactions between categorical and continuous variables. Br J Math Stat Psychol. 2019;72(1):136-154. DOI: 10.1111/bmsp.12147 DOI: https://doi.org/10.1111/bmsp.12147
22. Hosoya H, Kitaura H, Hashimoto T, Ito M, Kinbara M, Deguchi T, et al. Relationship between sleep bruxism and sleep respiratory events in patients with obstructive sleep apnea syndrome. Sleep and Breathing. 2014;18(4):837–44. DOI: 10.1007/s11325-014-0953-5 DOI: https://doi.org/10.1007/s11325-014-0953-5
23. Macaluso GM, Guerra P, Di Giovanni G, Boselli M, Parrino L, Terzano MG. Sleep bruxism is a disorder related to periodic arousals during sleep. J Dent Res. 1998;77(4):565-73. DOI: 10.1177/00220345980770040901. DOI: https://doi.org/10.1177/00220345980770040901
24. Kato T, Montplaisir JY, Guitard F, Sessle BJ, Lund JP, Lavigne GJ. Evidence that experimentally induced sleep bruxism is a consequence of transient arousal. J Dent Res. 2003;82(4):284-8. DOI: 10.1177/154405910308200408. DOI: https://doi.org/10.1177/154405910308200408
25. Saito M, Yamaguchi T, Mikami S, Watanabe K, Gotouda A, Okada K, Hishikawa R, Shibuya E, Shibuya Y, Lavigne G. Weak association between sleep bruxism and obstructive sleep apnea. A sleep laboratory study. Sleep Breath. 2016;20(2):703-9. DOI: 10.1007/s11325-015-1284-x. DOI: https://doi.org/10.1007/s11325-015-1284-x
26. da Costa Lopes AJ, Cunha TCA, Monteiro MCM, Serra-Negra JM, Cabral LC, Júnior PCS. Is there an association between sleep bruxism and obstructive sleep apnea syndrome? A systematic review. Sleep Breath. 2020;24(3):913-921. DOI: 10.1007/s11325-019-01919-y. DOI: https://doi.org/10.1007/s11325-019-01919-y
27. Lavigne GJ, Kato T, Kolta A, Sessle BJ. Neurobiological mechanisms involved in sleep bruxism. Crit Rev Oral Biol Med. 2003;14(1):30-46. DOI: 10.1177/154411130301400104. DOI: https://doi.org/10.1177/154411130301400104
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