Impact of New Ventilation and Hemodynamic Support Strategies on the Recovery of Critically Ill Patients with Acute Respiratory Distress Syndrome due to Sepsis: A Systematic Review
DOI:
https://doi.org/10.56294/saludcyt20251320Keywords:
Acute Respiratory Distress Syndrome, Sepsis, Ventilation Strategies, Hemodynamic Support, Systematic ReviewAbstract
Acute Respiratory Distress Syndrome (ARDS) is a complication caused by sepsis and present burden in critical care with high mortality and limited effective treatments. Advances in ventilation and hemodynamic support offer potential to improve recovery. Our aim is to systematically evaluate impact of new ventilation and hemodynamic strategies on the recovery of critically ill patients with ARDS due to sepsis. The research is conducted on Web of Science, PubMed, Embase, and Cochrane Library from January 2000 to December 2023. We selected randomized controlled trials and observational studies that looked at adult ARDS patients with sepsis as the main cause were the main focus of the inclusion criteria. Advanced fluid management, extracorporeal membrane oxygenation (ECMO) and lung-protective ventilation were among the interventions. Survival rates, length of mechanical breathing oxygenation improvements and complication rates were among the outcomes examined. Low tidal volume ventilation reduced mortality from 31% to 40% and ventilator-induced lung injury. Research stated that prone positioning improved oxygenation and reduced mortality in moderate-to-severe ARDS. We documented ECMO offered survival benefits in refractory cases while conservative fluid strategies reduced ventilator days without impacting mortality. Advanced hemodynamic monitoring and titration improved perfusion and recovery. Certain interventions such as high-frequency oscillatory ventilation, showed limited benefit or increased risk. Emerging strategies in ventilation and hemodynamic support enhance outcomes in sepsis-induced ARDS through individualized care. Future research should refine these interventions to optimize recovery while minimizing risks.
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Copyright (c) 2025 Luisa Paulina Chafla Romero, Alexis Agustin Dunay Silva, Mónica Alexandra Caiza Asitimbay, Mauro Rubén Cushpa Guamán, Jonathan Gabriel Chuga Guaman, Juan Camilo López Bermeo, Felipe Jose Herrera Lozano , Syndy Katherine Guarin-Rivera (Author)
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