Acute flaccid myelitis presumably caused by herpes virus 6: a case report

Authors

  • Castro-Vera Angie Universidad de Guayaquil, Facultad de Ciencias Químicas. Guayaquil, Ecuador Author https://orcid.org/0000-0001-9976-9909
  • María Vivanco-Vega Universidad Católica Santiago de Guayaquil,Facultad de Ciencias Químicas, Posgrado de Pediatría. Guayaquil, Ecuador Author https://orcid.org/0009-0006-5482-2060
  • Rubén Riera-Pazmiño Universidad Católica Santiago de Guayaquil,Facultad de Ciencias Químicas, Posgrado de Pediatría. Guayaquil, Ecuador Author https://orcid.org/0009-0007-6196-083X
  • Evelyn Haro-Romero Universidad Católica Santiago de Guayaquil,Facultad de Ciencias Químicas, Posgrado de Pediatría. Guayaquil, Ecuador Author
  • Silvia Guaigua-López Universidad Católica Santiago de Guayaquil, Facultad de Ciencias Químicas, Posgrado de Pediatría. Guayaquil, Ecuador Author https://orcid.org/0000-0002-4766-5267
  • Angélica Oña-Bueno Universidad Católica Santiago de Guayaquil, Facultad de Ciencias Químicas, Posgrado de Pediatría. Guayaquil, Ecuador Author https://orcid.org/0009-0005-6933-4193

DOI:

https://doi.org/10.56294/saludcyt20251315

Keywords:

Case Report, Acute Flaccid Myelitis, Herpes Virus 6, Children

Abstract

INTRODUCTION: acute flaccid myelitis (AFM) is a rare pathology that mostly affects children. It is of uncertain etiology. It has been related to enteroviruses D68 and A71, as well as viruses such as herpesviruses. 
CASE REPORT: we reported the case of a 1-year-old child with symptoms of vomiting, abdominal pain, constipation and pain in the right lower limb. Consecutively, he presented thermal elevation, paralysis and areflexia of extremities. Only Herpes Virus 6 (HHV-6) was isolated. MRI was compatible with MFA. He had progressive clinical deterioration and died.
DISCUSSION: it was reported a case of a child with AFM presumably caused by HHV-6, since it was the only pathogen isolated. The rest of the tests were normal or negative. Based on his clinical and MRI findings, he was diagnosed with AFM. He had rapid progression of the disease, with a fatal outcome.
CONCLUSION: diagnosing this disease represents a great challenge. Therefore, early recognition of this pathology is imperative to avoid fatal outcomes.

 

References

1. Helfferich J, Bruijstens AL, Knoester M, Brouwer OF, Neuteboom RF. Comparison of acute flaccid myelitis and transverse myelitis in children and evaluation of diagnostic criteria. Eur J Neurol. el 1 de agosto de 2023;30(8):2430–41.

2. Helfferich J, Roodbol J, de Wit MC, Brouwer OF, Jacobs BC, Aberle SW, et al. Acute flaccid myelitis and Guillain–Barré syndrome in children: A comparative study with evaluation of diagnostic criteria. Eur J Neurol. el 1 de febrero de 2022;29(2):593–604.

3. Sejvar JJ, Lopez AS, Cortese MM, Leshem E, Pastula DM, Miller L, et al. Acute Flaccid Myelitis in the United States, August-December 2014: Results of Nationwide Surveillance. Clinical Infectious Diseases. el 15 de septiembre de 2016;63(6):737–45.

4. Fang X, Huda R. Acute flaccid myelitis: Current status and diagnostic challenges. Vol. 16, Journal of Clinical Neurology (Korea). Korean Neurological Association; 2020. p. 376–82.

5. Murphy OC, Messacar K, Benson L, Bove R, Carpenter JL, Crawford T, et al. Acute flaccid myelitis: cause, diagnosis, and management. Vol. 397, The Lancet. Lancet Publishing Group; 2021. p. 334–46.

6. Yarovaya K, Rayi A. Acute Flaccid Myelitis. Treasure Island (FL): StatPearls; 2024.

7. Hopkins SE, Desai J, Benson L. Acute Flaccid Myelitis: A Call for Vigilance and an Update on Management. Pediatr Neurol. el 1 de enero de 2021;114:26–8.

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Published

2025-01-02

How to Cite

1.
Castro-Vera A, Vivanco-Vega M, Riera-Pazmiño R, Haro-Romero E, Guaigua-López S, Oña-Bueno A. Acute flaccid myelitis presumably caused by herpes virus 6: a case report. Salud, Ciencia y Tecnología [Internet]. 2025 Jan. 2 [cited 2025 Jan. 15];5:1315. Available from: https://sct.ageditor.ar/index.php/sct/article/view/1315